Sorbitan monostearate, ethoxylated

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from secondary literature

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka).

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Oryzias latipes

Details on test organisms:

- Common name: Japanese Medaka

Test type:

static

Water media type:

freshwater

Total exposure duration:

24 h

Test temperature:

10°C, 20°C, 30°C

Reference substance (positive control):

no

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: At 10°C and 20°C

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

520 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

no

Conclusions:

The lethal concentration (LC50) value of test chemical on fish (Oryzias latipes) in a 24 hr and 48 hrs study on the basis of mortality effect was estimated to be >1000 mg/L.

Executive summary:

Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). The lethal concentration (LC50) value of test chemical on fish (Oryzias latipes) in a 24 hr and 48 hrs study on the basis of mortality effect was estimated to be >1000 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance, it is concluded that test chemical could not exhibit short term toxicity to fish (Oryzias latipes).

Description of key information

Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). The lethal concentration (LC50) value of test chemical on fish (Oryzias latipes) in a 24 hr and 48 hrs study on the basis of mortality effect was estimated to be >1000 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance, it is concluded that test chemical could not exhibit short term toxicity to fish (Oryzias latipes).

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

260 mg/L

Additional information

Summarized result for the toxicity of test chemical on mortality of fish were carried out and mention as below:

Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). The lethal concentration (LC50) value of test chemical on fish (Oryzias latipes) in a 24 hr and 48 hrs study on the basis of mortality effect was estimated to be >1000 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance, it is concluded that test chemical could not exhibit short term toxicity to fish (Oryzias latipes).

 

First study was supported by the second study from secondary source. Short term toxicity of test chemical were studied on the mortality of fish Oryzias latipes (Japanese Medaka). Test conducted under the static system for 48 hrs. Based on the mortality of fish Oryzias latipes (Japanese Medaka) by the chemical incubation for 24 and 48 hrs, the LC50 was observed at 260 mg/l and 240 mg/l. Thus on the basis of LC50 value, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Thus on the basis of LC50 value, chemical consider to be nontoxic and not classified as per the CLP classification criteria.