Bis(2-ethylhexyl) 2,2'-thiobisacetate

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given. The omission of a 3rd animal does not affect the outcome of classification.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

yes

Remarks:

2 animals only

Principles of method if other than guideline:

Only a rough summary is available, but the method of application seems to be similar to OECD TG 405.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2-ethylhexyl) 2,2'-thiobisacetate

EC Number:

246-131-9

EC Name:

Bis(2-ethylhexyl) 2,2'-thiobisacetate

Cas Number:

24293-43-4

Molecular formula:

C20H38O4S

IUPAC Name:

2-ethylhexyl 2-({2-[(2-ethylhexyl)oxy]-2-oxoethyl}sulfanyl)acetate

Test material form:

solid - liquid: suspension

Details on test material:

- Name of test material (as cited in study report): Weichmacher VP KA 9073
- Analytical purity: not reported

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Source: Not reported
- Housing: Individually

Test system

Vehicle:

not specified

Controls:

no

Amount / concentration applied:

500 mg/100µL/animal

Duration of treatment / exposure:

single dose

Observation period (in vivo):

7 days

Number of animals or in vitro replicates:

2

Results and discussion

In vivo

Results

Irritation parameter:

other: overall observation

Basis:

other: two animals

Time point:

other: 7 days

Score:

0

Reversibility:

other: not applicable

Any other information on results incl. tables

The test substance was reported to be not irritating to the rabbit eye under the conditions of this study.

However, there are major reporting deficits, the eye scoring system is unclear and only two animals were treated.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

Based on the study results, no classification is required.

Executive summary:

In an eye irritation study summary, 0.1 mL containing 500 mg of the test substance was instilled into the conjunctival sac of two New Zealand White rabbits. No further details were given in the short report. The substance was reported to be not irritating to the eye.