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Diss Factsheets
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EC number: 915-926-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- other: Expert statement
- Adequacy of study:
- key study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: All available information on physical, chemical and toxicological properties were evaluated.
- Conclusions:
- No bio-accumulation expected. The test item is expected to be bioavailable via oral and dermal routes and distributed throughout the organism. Significant metabolism is anticipated due to the similarity to fatty acids. Excretion of degradation products via kidneys and lungs (CO2) is also expected.
- Executive summary:
Humectol C is produced and handled as a reaction mass of sodium hydrogen N,N-dibutyl-10-(sulphonatooxy)-octadecane-amidate and sodium sulpho-octadecanoate containing at least 47 components. None of these components is present at more than 5 %. The structures are mainly sulfated fatty acid (saturated as well as unsaturated) and sulfated fatty acid amides with secondary amine moieties. The molecules are supposed to have a variable structures made of long non-polar chains with polar groups (sulfate, carboxylate, carbamide) attached. Sulfate-cross-linked material is also present. The molecular weight of this material is mostly between 250 and ca. 800 Dalton.
Absorption: Humectol C is soluble in water up to 2.99 g/L and the organic chains will lead to a significant solubility in lipids. Therefore, at least the smaller and non-polar molecules are expected to be readily bio-available through the skin as well as after oral exposure Depending on the number of sulfate moieties in the molecules the absorption might, however, be compound- and route-specifically variable.
Distribution: After absorption distribution throughout the organism is expected. A specific potential for accumulation in e. g. fatty tissue is not anticipated due to the possible degradation and the polar groups in most of the involved compounds.
Metabolism: Humectol C has mostly a molecular weight below 800 Dalton and is quite soluble at physiologic pH. The molecular structures resemble fatty acids and amides. These structures are expected to be accessible to biotransformation and degradation by hydrolysis and oxidation. Parts of the fatty acid chains might be introduced to the normal fat metabolism.
Elimination: As Humectol C is expected to become available to metabolism and transport in a living organism, it is expected to degrade to carbon dioxide, water, sulfate and nitrogen compounds. Carbon dioxide will be exhaled and the other products are likely to be excreted via the normal excretory organs (kidney or liver/gall bladder). If applied orally some of the material may be eliminated via the feces.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Absorption: Humectol C is soluble in water up to 2.99 g/L and the organic chains will lead to a significant solubility in lipids. Therefore, at least the smaller and non-polar molecules are expected to be readily bio-available through the skin as well as after oral exposure Depending on the number of sulfate moieties in the molecules the absorption might, however, be compound- and route-specifically variable.
Distribution: After absorption distribution throughout the organism is expected. A specific potential for accumulation in e. g. fatty tissue is not anticipated due to the possible degradation and the polar groups in most of the involved compounds.
Metabolism: Humectol C has mostly a molecular weight below 800 Dalton and is quite soluble at physiologic pH. The molecular structures resemble fatty acids and amides. These structures are expected to be accessible to biotransformation and degradation by hydrolysis and oxidation. Parts of the fatty acid chains might be introduced to the normal fat metabolism.
Elimination: As Humectol C is expected to become available to metabolism and transport in a living organism, it is expected to degrade to carbon dioxide, water, sulfate and nitrogen compounds. Carbon dioxide will be exhaled and the other products are likely to be excreted via the normal excretory organs (kidney or liver/gall bladder). If applied orally some of the material may be eliminated via the feces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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