Proposals to identify Substances of Very High Concern previous consultations

In the framework of the authorisation process, Member States Competent Authorities or the European Chemicals Agency (ECHA), on request of the European Commission, may prepare Annex XV dossiers for the identification of Substances of Very High Concern (SVHC). SVHC are defined in Article 57 of Regulation (EC) No 1907/2006 ("the REACH Regulation") and include substances which are:

  • Carcinogenic, Mutagenic or toxic to Reproduction (CMR), meeting the criteria for classification in category 1 or 2 in accordance with Directive 67/548/EEC. This directive was replaced in beginning of 2009 by the new EU regulation (EC) No 1272/2008 on classification, labelling and packaging of chemical substances and mixtures, the so-called CLP Regulation. According to the new CLP Regulation these substances shall be classified as 1a or 1b.
  •  Persistent, Bioaccumulative and Toxic (PBT) or very Persistent and very Bioaccumulative (vPvB) according to the criteria in Annex XIII of the REACH Regulation,
  •  Identified, on a case-by-case basis, from scientific evidence as causing probable serious effects to human health or the environment of an equivalent level of concern as those above (e.g. endocrine disrupters)

The Annex XV reports, prepared by a Member State or the Agency, are available in the table below for information. Interested parties have 45 days from the date of publication to provide comments to the Agency on the identification of the substance as SVHC as well as further information related to use, exposure, alternatives and risks. 

 
(±)-1,7,7-trimethyl-3-[(4-methylphenyl)methylene]bicyclo[2.2.1]heptane-2-one (4-methylbenzylidene camphor) 253-242-6 36861-47-9 Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 29/02/2016 14/04/2016
1,2,3 Trichlorobenzene 201-757-1 87-61-6 Germany PBT like substance (equivalent level of concern) 30/08/2010 14/10/2010
1,2,3-trichloropropane 202-486-1 96-18-4 ECHA Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 21/02/2011 07/04/2011
1,2,4 Trichlorobenzene 204-428-0 120-82-1 Germany Equivalent level of concern having probable serious effects to human health and environment (Article 57 f) 30/08/2010 14/10/2010
1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters; 1,2-benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5)
271-094-0
272-013-1
68515-51-5
68648-93-1
Sweden Toxic for Reproduction (Article 57 c) 02/03/2015 16/04/2015
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich 276-158-1 71888-89-6 ECHA Toxic for reproduction (Article 57 c) 21/02/2011 07/04/2011
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters 271-084-6 68515-42-4 Denmark Toxic for reproduction (Article 57 c) 21/02/2011 07/04/2011
1,2-Benzenedicarboxylic acid, dihexylester, branched and linear 271-093-5 68515-50-4 Sweden Toxic for reproduction (Article 57 c) 03/03/2014 17/04/2014
1,2-Benzenedicarboxylic acid, dipentylester, branched and linear 284-032-2 84777-06-0 Germany Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
1,2-bis(2-methoxyethoxy)ethane (TEGDME,triglyme) 203-977-3 112-49-2 Belgium Toxic for reproduction (Article 57 c) 27/02/2012 12/04/2012
1,2-Dichloroethane (EDC) 203-458-1 107-06-2 Slovakia Carcinogenic (Article 57a) 29/08/2011 13/10/2011
1,2-Diethoxyethane 211-076-1 629-14-1 Slovakia Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
1,2-dimethoxyethane,ethylene glycol dimethyl ether (EGDME) 203-794-9 110-71-4 Belgium Toxic for reproduction (Article 57 c) 27/02/2012 12/04/2012
1,3,5 Trichlorobenzene 203-608-6 108-70-3 Germany PBT like substance (equivalent level of concern) 30/08/2010 14/10/2010
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) 219-514-3 2451-62-9 Netherlands Mutagenic (Article 57b) 27/02/2012 12/04/2012
1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) 423-400-0 59653-74-6 Netherlands Mutagenic (Article 57b) 27/02/2012 12/04/2012
1,3-propanesultone 214-317-9 1120-71-4 ECHA Carcinogenic (Article 57 a) 31/08/2015 15/10/2015
1,6,7,8,9,14,15,16,17,17,18,18-Dodecachloropentacyclo[12.2.1.16,9.02,13.05,10]octadeca-7,15-diene (“Dechlorane Plus”™) - - United Kingdom vPvB (Article 57e) 05/09/2017 20/10/2017
1,7,7-trimethyl-3-(phenylmethylene)bicyclo[2.2.1]heptan-2-one (3-benzylidene camphor) 239-139-9 15087-24-8 Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 29/02/2016 14/04/2016
1-bromopropane (n-propyl bromide) 203-445-0 106-94-5 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
1-Methyl-2-pyrrolidone (NMP) 212-828-1 872-50-4 ECHA Toxic for reproduction (Article 57 c) 21/02/2011 07/04/2011
2,2'-dichloro-4,4'-methylenedianiline (MOCA) 202-918-9 101-14-4 ECHA Carcinogenic (Article 57a) 29/08/2011 13/10/2011
2,2-bis(4'-hydroxyphenyl)-4-methylpentane 401-720-1 6807-17-6 Sweden Toxic for reproduction (Article 57c) 04/09/2018 19/10/2018
2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327) 223-383-8 3864-99-1 Germany vPvB (Article 57 e) 04/03/2013 18/04/2013
2,4-di-tert-butyl-6-(5-chlorobenzotriazol-2-yl)phenol (UV-327) 223-383-8 3864-99-1 Germany vPvB (Article 57 e) 31/08/2015 15/10/2015
2,4-Dinitrotoluene 204-450-0 121-14-2 Spain Carcinogenic (Article 57a) 31/08/2009 15/10/2009
2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328) 247-384-8 25973-55-1 Germany PBT (Article 57 d);
vPvB (Article 57 e)
01/09/2014 16/10/2014
2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350) 253-037-1 36437-37-3 Germany vPvB (Article 57 e) 04/03/2013 18/04/2013
2-(2H-benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (UV-350) 253-037-1 36437-37-3 Germany vPvB (Article 57 e) 31/08/2015 15/10/2015
2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320) 223-346-6 3846-71-7 Germany PBT (Article 57 d);
vPvB (Article 57 e)
01/09/2014 16/10/2014
2-Ethoxyethanol 203-804-1 110-80-5 Austria Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
2-Ethoxyethyl acetate 203-839-2 111-15-9 Belgium Toxic for reproduction (Article 57 c) 21/02/2011 07/04/2011
2-Methoxyaniline,o-Anisidine 201-963-1 90-04-0 Germany Carcinogenic (Article 57a) 29/08/2011 13/10/2011
2-Methoxyethanol 203-713-7 109-86-4 Austria Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
3-ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine 421-150-7 143860-04-2 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
4,4'- Diaminodiphenylmethane (MDA) 202-974-4 101-77-9 Germany Carcinogenic (Article 57a) 30/06/2008 14/08/2008
4,4'-bis(dimethylamino)-4''-(methylamino)trityl alcohol [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 209-218-2 561-41-1 ECHA Carcinogenic (Article 57a) 27/02/2012 12/04/2012
4,4'-bis(dimethylamino)benzophenone (Michler’s ketone) 202-027-5 90-94-8 ECHA Carcinogenic (Article 57a) 27/02/2012 12/04/2012
4,4'-isopropylidenediphenol (bisphenol A; BPA) 201-245-8 80-05-7 France Endocrine disrupting properties (Article 57(f) - human health) 09/03/2017 24/04/2017
4,4'-methylenedi-o-toluidine 212-658-8 838-88-0 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
4,4'-oxydianiline and its salts 202-977-0 101-80-4 ECHA Carcinogenic (Article 57a); Mutagenic (Article 57b) 03/09/2012 18/10/2012
4,4’-isopropylidenediphenol (bisphenol A) 201-245-8 80-05-7 France Toxic for reproduction (Article 57 c) 06/09/2016 21/10/2016
4,4’-isopropylidenediphenol (bisphenol A; BPA) 201-245-8 80-05-7 Germany Endocrine disrupting properties (Article 57(f) – environment) 05/09/2017 20/10/2017
4-(1,1,3,3-tetramethylbutyl)phenol, (4-tert-Octylphenol) 205-426-2 140-66-9 Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 29/08/2011 13/10/2011
4-(1,1,3,3-tetramethylbutyl)phenol, ethoxylated [covering well-defined substances and UVCB substances, polymers and homologues] - - Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 03/09/2012 18/10/2012
4-Aminoazobenzene 200-453-6 60-09-3 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
4-Heptylphenol, branched and linear [substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof] - - Austria Equivalent level of concern having probable serious effects to the environment (Article 57 f) 06/09/2016 21/10/2016
4-methyl-m-phenylenediamine (toluene-2,4-diamine) 202-453-1 95-80-7 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
4-Nonylphenol, branched and linear [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof] - - Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 03/09/2012 18/10/2012
4-Nonylphenol, branched and linear, ethoxylated [substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof] - - Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 04/03/2013 18/04/2013
4-tert-butylphenol 202-679-0 98-54-4 Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 06/09/2016 21/10/2016
5-sec-butyl-2-(2,4-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [1], 5-sec-butyl-2-(4,6-dimethylcyclohex-3-en-1-yl)-5-methyl-1,3-dioxane [2] [covering any of the individual isomers of [1] and [2] or any combination thereof] - - Netherlands vPvB (Article 57 e) 02/03/2015 16/04/2015
5-tert-butyl-2,4,6-trinitro-m-xylene (Musk xylene) 201-329-4 81-15-2 Netherlands vPvB (Article 57 e) 30/06/2008 14/08/2008
6-methoxy-m-toluidine (p-cresidine) 204-419-1 120-71-8 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
[4-[4,4'-bis(dimethylamino) benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride (C.I. Basic Violet 3) [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 208-953-6 548-62-9 ECHA Carcinogenic (Article 57a) 27/02/2012 12/04/2012
[4-[[4-anilino-1-naphthyl][4-(dimethylamino)phenyl]methylene]cyclohexa-2,5-dien-1-ylidene] dimethylammonium chloride (C.I. Basic Blue 26) [with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)] 219-943-6 2580-56-5 ECHA Carcinogenic (Article 57a) 27/02/2012 12/04/2012
[Phthalato(2-)]dioxotrilead 273-688-5 69011-06-9 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Acetic acid, lead salt, basic 257-175-3 51404-69-4 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Acids generated from chromium trioxide and their oligomers. Names of the acids and their oligomers: Chromic acid, Dichromic acid, Oligomers of chromic acid and dichromic acid.
231-801-5
236-881-5
7738-94-5
13530-68-2
Germany Carcinogenic (Article 57a) 30/08/2010 14/10/2010
Acrylamide 201-173-7 79-06-1 Netherlands Carcinogenic (Article 57a); Mutagenic (Article 57b) 31/08/2009 15/10/2009
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins) 287-476-5 85535-84-8 United Kingdom PBT (Article 57 d); vPvB (Article 57 e) 30/06/2008 14/08/2008
Aluminosilicate Refractory Ceramic Fibres (RCF) - - Germany Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Aluminosilicate, Refractory Ceramic Fibres - - Germany Carcinogenic (Article 57a) 31/08/2009 15/10/2009
Ammonium dichromate 232-143-1 7789-09-5 France Carcinogenic (Article 57a); Mutagenic (Article 57b); Toxic for reproduction (Article 57 c) 08/03/2010 22/04/2010
Ammonium pentadecafluorooctanoate (APFO) 223-320-4 3825-26-1 Germany Toxic for reproduction (Article 57 c); PBT (Article 57 d) 04/03/2013 18/04/2013
Anthracene 204-371-1 120-12-7 Germany PBT (Article 57 d) 30/06/2008 14/08/2008
Anthracene oil 292-602-7 90640-80-5 Germany Carcinogenic (Article 57a); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Anthracene oil, anthracene paste 292-603-2 90640-81-6 Germany Carcinogenic (Article 57a); Mutagenic (Article 57b); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Anthracene oil, anthracene paste, anthracene fraction 295-275-9 91995-15-2 Germany Carcinogenic (Article 57a); Mutagenic (Article 57b); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Anthracene oil, anthracene paste, distn. Lights 295-278-5 91995-17-4 Germany Carcinogenic (Article 57a); Mutagenic (Article 57b); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Anthracene oil, anthracene-low 292-604-8 90640-82-7 Germany Carcinogenic (Article 57a); Mutagenic (Article 57b); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Arsenic acid 231-901-9 7778-39-4 Norway Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Benz[a]anthracene 200-280-6 56-55-3 Germany Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
05/09/2017 20/10/2017
Benzene-1,2,4-tricarboxylic acid 1,2-anhydride (trimellitic anhydride) 209-008-0 552-30-7 Netherlands Equivalent level of concern having probable serious effects to human health (Article 57 f) 06/09/2016 21/10/2016
Benzo[def]chrysene (Benzo[a]pyrene) 200-028-5 50-32-8 Germany Carcinogenic (Article 57 a)
Mutagenic (Article 57 b)
Toxic for reproduction (Article 57 c)
PBT (Article 57 d)
vPvB (Article 57 e)
29/02/2016 14/04/2016
Benzo[ghi]perylene 205-883-8 191-24-2 Denmark PBT (Article 57 d); vPvB Art.57(e) 08/03/2018 23/04/2018
Benzo[k]fluoranthene 205-916-6 207-08-9 Belgium Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
04/09/2018 19/10/2018
Benzyl butyl phthalate (BBP) 201-622-7 85-68-7 Austria Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Benzyl butyl phthalate (BBP) 201-622-7 85-68-7 Denmark Equivalent level of concern having probable serious effects to human health and the environment (Article 57 f) 01/09/2014 16/10/2014
Biphenyl-4-ylamine 202-177-1 92-67-1 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
Bis (2-ethylhexyl)phthalate (DEHP) 204-211-0 117-81-7 Sweden Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Bis(2-ethylhexyl) phthalate (DEHP) 204-211-0 117-81-7 Denmark Equivalent level of concern having probable serious effects to human health and the environment(Article 57 f) 01/09/2014 16/10/2014
Bis(2-methoxyethyl) ether 203-924-4 111-96-6 Austria Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
Bis(2-methoxyethyl) phthalate 204-212-6 117-82-8 Germany Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
Bis(pentabromophenyl) ether (decabromodiphenyl ether) (DecaBDE) 214-604-9 1163-19-5 United Kingdom PBT (Article 57 d); vPvB (Article 57 e) 03/09/2012 18/10/2012
Bis(tributyltin) oxide (TBTO) 200-268-0 56-35-9 Norway PBT (Article 57 d) 30/06/2008 14/08/2008
Boric acid
233-139-2
234-343-4
10043-35-3
11113-50-1
Germany Toxic for reproduction (Article 57 c) 08/03/2010 22/04/2010
Cadmium 231-152-8 7440-43-9 Sweden Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) 04/03/2013 18/04/2013
Cadmium nitrate 233-710-6 10325-94-7 Sweden Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
05/09/2017 20/10/2017
Cadmium carbonate 208-168-9 513-78-0 Sweden Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
05/09/2017 20/10/2017
Cadmium chloride 233-296-7 10108-64-2 Sweden Carcinogenic (Article 57a); Mutagenic (Article 57(b); Toxic for Reproduction (Article 57(c); Equivalent level of concern having probable serious effects to human health (Article 57 f) 03/03/2014 17/04/2014
Cadmium fluoride 232-222-0 7790-79-6 Sweden Carcinogenic (Article 57 a);
Mutagenic (Article 57 b);
Toxic for Reproduction (Article 57 c);
Equivalent level of concern having probable serious effects to human health (Article 57 f)
01/09/2014 16/10/2014
Cadmium hydroxide 244-168-5 21041-95-2 Sweden Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
05/09/2017 20/10/2017
Cadmium oxide 215-146-2 1306-19-0 Sweden Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) 04/03/2013 18/04/2013
Cadmium sulphate 233-331-6
10124-36-4
31119-53-6
Sweden Carcinogenic (Article 57 a);
Mutagenic (article 57 b);
Toxic for Reproduction (Article 57 c);
Equivalent level of concern having probable serious effects to human health (Article 57 f)
01/09/2014 16/10/2014
Cadmium sulphide 215-147-8 1306-23-6 Sweden Carcinogenic (Article 57a); Equivalent level of concern having probable serious effects to human health (Article 57 f) 02/09/2013 17/10/2013
Calcium arsenate 231-904-5 7778-44-1 Norway Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Chromium trioxide 215-607-8 1333-82-0 Germany Carcinogenic (Article 57a); Mutagenic (Article 57b) 30/08/2010 14/10/2010
Chrysene 205-923-4 218-01-9 Germany Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
05/09/2017 20/10/2017
Cobalt dichloride 231-589-4 7646-79-9 France Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Cobalt(II) carbonate 208-169-4 513-79-1 Netherlands Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
Cobalt(II) diacetate 200-755-8 71-48-7 Netherlands Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
Cobalt(II) dinitrate 233-402-1 10141-05-6 Netherlands Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
Cobalt(II) sulphate 233-334-2 10124-43-3 Netherlands Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/08/2010 14/10/2010
Cyclododecane 206-033-9 294-62-2 France PBT (Article 57 d) 30/06/2008 14/08/2008
Cyclohexane-1,2-dicarboxylic anhydride [1], cis-cyclohexane-1,2-dicarboxylic anhydride [2], trans-cyclohexane-1,2-dicarboxylic anhydride [3] [The individual cis- [2] and trans- [3] isomer substances and all possible combinations of the cis- and trans-isomers [1] are covered by this entry]
201-604-9
236-086-3
238-009-9
85-42-7
13149-00-3
14166-21-3
Netherlands Equivalent level of concern having probable serious effects to human health (Article 57 f) 03/09/2012 18/10/2012
Decamethylcyclopentasiloxane (D5) 208-764-9 541-02-6 Germany PBT (Article 57d); vPvB (Article 57e) 08/03/2018 23/04/2018
Diarsenic pentaoxide 215-116-9 1303-28-2 France Carcinogenic (Article 57a) 30/06/2008 14/08/2008
Diarsenic trioxide 215-481-4 1327-53-3 France Carcinogenic (Article 57a) 30/06/2008 14/08/2008
Diazene-1,2-dicarboxamide (C,C`-azodi(formamide)) (ADCA) 204-650-8 123-77-3 Austria Equivalent level of concern having probable serious effects to human health (Article 57 f) 03/09/2012 18/10/2012
Diboron trioxide 215-125-8 1303-86-2 Germany Toxic for reproduction (Article 57 c) 27/02/2012 12/04/2012
Dibutyl phthalate 201-557-4 84-74-2 Austria Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Dibutyl phthalate (DBP) 201-557-4 84-74-2 Denmark Equivalent level of concern having probable serious effects to human health and the environment (Article 57 f) 01/09/2014 16/10/2014
Dibutyltin dichloride (DBTC) 211-670-0 683-18-1 Sweden Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Dichromium tris(chromate) 246-356-2 24613-89-6 France Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Dicyclohexyl phthalate 201-545-9 84-61-7 Sweden Toxic for reproduction (Article 57 c); Equivalent level of concern having probable serious effects to human health and the environment (Article 57 f) 31/08/2015 15/10/2015
Dicyclohexyl phthalate (DCHP) 201-545-9 84-61-7 Sweden Toxic for reproduction (Article 57 c)
Equivalent level of concern having probable serious effects to human health and the environment (Article 57 f)
29/02/2016 14/04/2016
Diethyl sulphate 200-589-6 64-67-5 ECHA Carcinogenic (Article 57a); Mutagenic (Article 57b) 03/09/2012 18/10/2012
Dihexyl phthalate 201-559-5 84-75-3 Germany Toxic for reproduction (Article 57 c) 02/09/2013 17/10/2013
Diisobutyl phthalate 201-553-2 84-69-5 Germany Toxic for reproduction (Article 57 c) 31/08/2009 15/10/2009
Diisobutyl phthalate (DIBP) 201-553-2 84-69-5 Denmark Equivalent level of concern having probable serious effects to human health and the environment (Article 57 f) 01/09/2014 16/10/2014
Diisopentylphthalate 210-088-4 605-50-5 Austria Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Dimethyl sulphate 201-058-1 77-78-1 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
Dinoseb (6-sec-butyl-2,4-dinitrophenol) 201-861-7 88-85-7 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Dioctyltin bis(2-ethylhexyl mercaptoacetate), 2-Ethylhexyl 10-ethyl-4,4- dioctyl-7-oxo-8-oxa-3,5-dithia- 4-stannatetradecanoate 239-622-4 15571-58-1 Austria Toxic for Reproduction (Article 57 c) 01/09/2014 16/10/2014
Dioxobis(stearato)trilead 235-702-8 12578-12-0 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Dipentyl phthalate (DPP) 205-017-9 131-18-0 Poland Toxic for reproduction (Article 57 c) 04/03/2013 18/04/2013
Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) (C.I. Direct Red 28) 209-358-4 573-58-0 Netherlands Carcinogenic (Article 57a) 02/09/2013 17/10/2013
Disodium 4-amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo] -5-hydroxy-6-(phenylazo)naphthalene-2,7-disulphonate (C.I. Direct Black 38) 217-710-3 1937-37-7 Netherlands Carcinogenic (Article 57a) 02/09/2013 17/10/2013
Disodium octaborate 234-541-0 12008-41-2 Sweden Toxic for reproduction (Article 57c) 08/03/2018 23/04/2018
Disodium tetraborate, anhydrous 215-540-4
1303-96-4
1330-43-4
12179-04-3
Denmark Toxic for reproduction (Article 57 c) 08/03/2010 22/04/2010
Dodecamethylcyclohexasiloxane (D6) 208-762-8 540-97-6 ECHA PBT (Article 57d)
vPvB (Article 57e)
08/03/2018 23/04/2018
Ethylenediamine 203-468-6 107-15-3 ECHA Respiratory sensitising properties (Article 57(f) - human health) 08/03/2018 23/04/2018
Fatty acids, C16-18, lead salts 292-966-7 91031-62-8 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Fluoranthene 205-912-4 206-44-0 Belgium PBT (Article 57d)
vPvB (Article 57e)
04/09/2018 19/10/2018
Formaldehyde, oligomeric reaction products with aniline (technical MDA) 500-036-1 25214-70-4 Germany Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Formamide 200-842-0 75-12-7 Germany Toxic for reproduction (Article 57 c) 27/02/2012 12/04/2012
Furan 203-727-3 110-00-9 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
Henicosafluoroundecanoic acid 218-165-4 2058-94-8 Germany vPvB (Article 57 e) 03/09/2012 18/10/2012
Heptacosafluorotetradecanoic acid 206-803-4 376-06-7 Germany vPvB (Article 57 e) 03/09/2012 18/10/2012
Hexabromocyclododecane (HBCDD) 247-148-4 25637-99-4 Sweden PBT (Article 57 d) 30/06/2008 14/08/2008
Hexahydromethylphthalic anhydride [1], Hexahydro-4-methylphthalic anhydride [2], Hexahydro-1-methylphthalic anhydride [3], Hexahydro-3-methylphthalic anhydride [4] [The individual isomers [2], [3] and [4] (including their cis- and trans- stereo isomeric forms) and all possible combinations of the isomers [1] are covered by this entry]
247-094-1
243-072-0
256-356-4
260-566-1
25550-51-0
19438-60-9
48122-14-1
57110-29-9
Netherlands Equivalent level of concern having probable serious effects to human health (Article 57 f) 03/09/2012 18/10/2012
hexamethylene diacrylate (hexane-1,6-diol diacrylate) 235-921-9 13048-33-4 Sweden Equivalent level of concern having probable serious effects to human health (Article 57 f) 31/08/2015 15/10/2015
Hydrazine 206-114-9
302-01-2
7803-57-8
ECHA Carcinogenic (Article 57a) 21/02/2011 07/04/2011
Imidazolidine-2-thione (2-imidazoline-2-thiol) 202-506-9 96-45-7 Sweden Toxic for reproduction (Article 57 c) 02/09/2013 17/10/2013
Lead 231-100-4 7439-92-1 Sweden Toxic for reproduction (Article 57c) 08/03/2018 23/04/2018
Lead bis(tetrafluoroborate) 237-486-0 13814-96-5 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead chromate 231-846-0 7758-97-6 France Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 31/08/2009 15/10/2009
Lead chromate molybdate sulphate red (C.I. Pigment Red 104) 235-759-9 12656-85-8 France Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 31/08/2009 15/10/2009
Lead cyanamidate 244-073-9 20837-86-9 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead di(acetate) 206-104-4 301-04-2 Netherlands Toxic for reproduction (Article 57 c) 02/09/2013 17/10/2013
Lead diazide, Lead azide 236-542-1 13424-46-9 ECHA Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
Lead dinitrate 233-245-9 10099-74-8 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead dipicrate 229-335-2 6477-64-1 ECHA Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
Lead hydrogen arsenate 232-064-2 7784-40-9 Norway Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Lead monoxide (lead oxide) 215-267-0 1317-36-8 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead oxide sulfate 234-853-7 12036-76-9 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead styphnate 239-290-0 15245-44-0 ECHA Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
Lead sulfochromate yellow (C.I. Pigment Yellow 34) 215-693-7 1344-37-2 France Carcinogenic (Article 57a); Toxic for reproduction (Article 57 c) 31/08/2009 15/10/2009
Lead titanium trioxide 235-038-9 12060-00-3 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead titanium zirconium oxide 235-727-4 12626-81-2 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Lead(II) bis(methanesulfonate) 401-750-5 17570-76-2 Netherlands Toxic for reproduction (Article 57 c) 27/02/2012 12/04/2012
Methoxyacetic acid 210-894-6 625-45-6 Sweden Toxic for reproduction (Article 57 c); equivalent level of concern having probable serious effects to human health and environment (Article 57 f) 03/09/2012 18/10/2012
Methyloxirane (Propylene oxide) 200-879-2 75-56-9 ECHA Carcinogenic (Article 57a); Mutagenic (Article 57b) 03/09/2012 18/10/2012
N,N,N',N'-tetramethyl-4,4'-methylenedianiline (Michler’s base) 202-959-2 101-61-1 ECHA Carcinogenic (Article 57a) 27/02/2012 12/04/2012
N,N-Dimethylacetamide (DMAC) 204-826-4 127-19-5 ECHA Toxic for reproduction (Article 57 c) 29/08/2011 13/10/2011
N,N-dimethylformamide 200-679-5 68-12-2 Sweden Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
N-methylacetamide 201-182-6 79-16-3 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
N-pentyl-isopentylphthalate - 776297-69-9 Germany Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Nitrobenzene 202-716-0 98-95-3 Austria Toxic for reproduction (Article 57 c) 31/08/2015 15/10/2015
Nonadecafluorodecanoic acid (PFDA) and its sodium and ammonium salts
206-400-3
-
221-470-5
335-76-2
3830-45-3
3108-42-7
Sweden Toxic for reproduction (Article 57 c); PBT (Article 57 d) 06/09/2016 21/10/2016
o-aminoazotoluene 202-591-2 97-56-3 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
o-Toluidine 202-429-0 95-53-4 ECHA Carcinogenic (Article 57a) 03/09/2012 18/10/2012
Octamethylcyclotetrasiloxane (D4) 209-136-7 556-67-2 Germany PBT (Article 57d)
vPvB (Article 57e)
08/03/2018 23/04/2018
Orange lead (lead tetroxide) 215-235-6 1314-41-6 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
p-(1,1-dimethylpropyl)phenol 201-280-9 80-46-6 Germany Equivalent level of concern having probable serious effects to the environment (Article 57 f) 06/09/2016 21/10/2016
Pentacosafluorotridecanoic acid 276-745-2 72629-94-8 Germany vPvB (Article 57 e) 03/09/2012 18/10/2012
Pentadecafluorooctanoic acid (PFOA) 206-397-9 335-67-1 Germany Toxic for reproduction (Article 57 c); PBT (Article 57 d) 04/03/2013 18/04/2013
Pentalead tetraoxide sulphate 235-067-7 12065-90-6 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Pentazinc chromate octahydroxide 256-418-0 49663-84-5 France Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Perfluorohexane-1-sulphonic acid and its salts 206-587-1 355-46-4 Sweden vPvB (Article 57e) 09/03/2017 24/04/2017
Perfluorononan-1-oic acid (2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoic acid and its sodium and ammonium salts 206-801-3
375-95-1
21049-39-8
4149-60-4
Sweden Toxic for reproduction (Article 57 c); PBT (Article 57 d) 31/08/2015 15/10/2015
Phenanthrene 201-581-5 85-01-8 France vPvB (Article 57e) 04/09/2018 19/10/2018
Phenolphthalein 201-004-7 77-09-8 ECHA Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Pitch, coal tar, high temp. 266-028-2 65996-93-2 Commission Carcinogenic (Article 57a); PBT (Article 57 d); vPvB (Article 57 e) 31/08/2009 15/10/2009
Potassium chromate 232-140-5 7789-00-6 France Carcinogenic (Article 57a); Mutagenic (Article 57b) 08/03/2010 22/04/2010
Potassium dichromate 231-906-6 7778-50-9 France Carcinogenic (Article 57a); Mutagenic (Article 57b); Toxic for reproduction (Article 57 c) 08/03/2010 22/04/2010
Potassium hydroxyoctaoxodizincatedichromate 234-329-8 11103-86-9 France Carcinogenic (Article 57a) 29/08/2011 13/10/2011
Pyrene 204-927-3 129-00-0 France PBT (Article 57d)
vPvB (Article 57e)
04/09/2018 19/10/2018
Pyrochlore, antimony lead yellow 232-382-1 8012-00-8 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Reaction mass of 2-ethylhexyl 10-ethyl-4,4-dioctyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate and 2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-4-octyl-7-oxo-8-oxa-3,5-dithia-4-stannatetradecanoate (reaction mass of DOTE and MOTE) - - Austria Toxic for Reproduction (Article 57 c) 01/09/2014 16/10/2014
Reaction products of 1,3,4-thiadiazolidine-2,5-dithione, formaldehyde and 4-heptylphenol, branched and linear (RP-HP) [with ≥0.1% w/w 4-heptylphenol, branched and linear] - - Austria Endocrine disrupting properties (Article 57(f) – environment) 05/09/2017 20/10/2017
Silicic acid (H2Si2O5), barium salt (1:1), lead-doped
[with lead (Pb) content above the applicable generic concentration limit for ’toxicity for reproduction’ Repr. 1A (CLP) or category 1 (DSD),the substance is a member of the group entry of lead compounds, with index number 082-001-00-6 in Regulation (EC) No 1272/2008]
272-271-5 68784-75-8 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Silicic acid, lead salt 234-363-3 11120-22-2 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012
Sodium chromate 231-889-5 7775-11-3 France Carcinogenic (Article 57a); Mutagenic (Article 57b); Toxic for reproduction (Article 57 c) 08/03/2010 22/04/2010
Sodium dichromate, dihydrate 234-190-3 7789-12-0 France Carcinogenic (Article 57a); Mutagenic (Article 57b); Toxic for reproduction (Article 57 c) 30/06/2008 14/08/2008
Sodium perborate,perboric acid, sodium salt
239-172-9
234-390-0
15120-21-5 Denmark Toxic for reproduction (Article 57 c) 03/03/2014 17/04/2014
Sodium peroxometaborate 231-556-4 7632-04-4 Denmark Toxic for reproduction (Article 57 c) 03/03/2014 17/04/2014
Strontium chromate 232-142-6 7789-06-2 France Carcinogenic (Article 57a) 21/02/2011 07/04/2011
Sulfurous acid, lead salt, dibasic 263-467-1 62229-08-7 ECHA Toxic for reproduction (Article 57 c) 03/09/2012 18/10/2012



* The Annex XV reports for 'Disodium tetraborate, anhydrous' and 'Tetraboron disodium heptaoxide, hydrate' are identical because these substances form the same compounds in aqueous solution and can be utilised for similar uses.

1) Index number in Annex VI of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006

2) European Chemicals Agency on request of the European Commission

3) In collaboration with Austria and Poland

4) Due to an administrative mistake the public consultation for the identification of cobalt dichloride as 'toxic for reproduction 1B' had to be re-launched for a new period of 45 days

Categories Display