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Diss Factsheets
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EC number: 439-070-6 | CAS number: 125005-87-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adequately reported study using a recognised test method (test group size larger than specified in relevant OECD guideline).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 6 test animals plus extra 3 given eyewash 30 seconds post-treatment
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 439-070-6
- EC Name:
- -
- Cas Number:
- 125005-87-0
- Molecular formula:
- Not applicable
- IUPAC Name:
- (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid acetic acid calcium dihydride hydrate magnesium dihydride potassium hydride sodium hydride
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- Adult
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Eyes checked pre-treatment, then untreated eye of each animal served as control
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- Single ocular administration (eyewash with water after 30 seconds for 3 rabbits in the extra group)
- Observation period (in vivo):
- 24, 48 and 72 hours post-treatment.
- Number of animals or in vitro replicates:
- 6 (plus 3 in extra eyewash group)
- Details on study design:
- Single treatment (eyewash for the extra group) followed by observations.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness and Discharge
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 80
- Reversibility:
- other: No cornea opacity observed
- Remarks on result:
- other: All scores zero.
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 10
- Reversibility:
- other: No effects observed
- Remarks on result:
- other: All scores zero.
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness and discharge
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 24 h
- Score:
- 4.3
- Max. score:
- 20
- Reversibility:
- fully reversible within: 48h
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness and Discharge
- Basis:
- mean
- Remarks:
- 6 animals (unwashed)
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 20
- Reversibility:
- fully reversible within: 48h
- Irritant / corrosive response data:
- Transient and minor reaction to treatment only.
Any other information on results incl. tables
Among the 3 additional, eyewashed animals, all scores were zero except for a single case of discharge (score 1), seen at 24h only (fully reversible within 48 hours).
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Not classified for eye irritation under EU criteria.
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