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Diss Factsheets
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EC number: 416-510-5 | CAS number: 667-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: public available literature, non GLP, non Guideline
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
- Objective of study:
- absorption
- excretion
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- not indicated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- body weight: about 100 g
Rats were fed with normal diet during the test period
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- ethanol
- Details on exposure:
- The test item was diluted in 50% ethanol (22.8 mg in 0.2 ml). 0.2 ml were dermally applied to the shaved neck of male rats. Control animals received 0.2 ml of 50% ethanol.
- Duration and frequency of treatment / exposure:
- one treatment only
Doses / concentrations
- Remarks:
- Doses / Concentrations:
22.8 mg in 0.2 ml 50% ethanol
- No. of animals per sex per dose / concentration:
- 9 males in exposure group
4 males in control group - Control animals:
- yes, concurrent vehicle
- Positive control reference chemical:
- no
- Details on study design:
- After dermal application, the urine of the animals was collected periodically during 5 days. The metabolite of the test item was measured in a bioassay.
- Details on dosing and sampling:
- The first measurement was done 18 after exposure. The next measurements were done every 24 h. The quantitative measurement of metabolite was done periodically in the urine samples. The samples were diluted with 100 mL water and the metabolite was detected using a microbiological assay.
- Statistics:
- mean and standard deviation
Results and discussion
- Preliminary studies:
- no preliminary results
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- At least 36 % of the dermally applied dose of the test item were bioavailable (excretion via the urine as metabolite).
- Details on distribution in tissues:
- Not measured.
- Details on excretion:
- At least 36 % of the dermally applied dose of the test item were found in the urine as metabolite.
Toxicokinetic parameters
- Test no.:
- #1
- Toxicokinetic parameters:
- AUC:
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The metabolite is formed from the test item. The same metabolite is formed after dermal application of structur analog.
Any other information on results incl. tables
It has been shown that following topical administration of the test item to rats, there is a rise in the urinary metabolite concentration (as measured by bioassay) with an AUC of approximately 70% of that for the same dose of topically applied structur analog. The Tmax of metabolite in urine following topical administration of the test item was delayed in comparison to topically applied structur analog. These data suggest that there is dermal penetration of the test item with associated extensive formation of metabolite.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
It has been shown that following topical administration of the test item to rats, there is a rise in the urinary main metabolite concentration (as measured by bioassay) with an AUC of approximately 70% of that for the same dose of topically applied test item analog. The Tmax of main metabolite in urine following topical administration of the test item was delayed in comparison to topically applied test item structure analog. These data suggest that there is dermal penetration of the test item with associated extensive formation of metabolite. These data support the test item as well as test item strucutre analog being vitamin B5 provitamins. - Executive summary:
In a absorption/excretion/metabolism study the test item was administered to 9 male Wistar rates dermally in a single dose of 22.8 mg in 0.2 ml 50% ethanol.
It has been shown that following topical administration of the test item to rats, there is a rise in the urinary main metabolite concentration (as measured by bioassay) with an AUC of approximately 70% of that for the same dose of topically applied test item structure analog. The Tmax of metabolite in urine following topical administration of the test item was delayed in comparison to topically applied test item structure analog. These data suggest that there is dermal penetration of the test item with associated extensive formation of metabolite. These data support the test item as well as test item structure analog being vitamin B5 provitamins.
At least 36 % of the dermally applied dose of the test item were bioavailable (excretion via the urine as metabolite).
This study in the rat is classified acceptable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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