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EC number: 932-389-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study similar to guideline with minor restrictions and under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- six rabbits were used, whereas the left flank was only clipped, the right flank was additionally abraded, at each flank two patches were applied, no observation was performed at 1 and at 48 h
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
- EC Number:
- 932-389-6
- Molecular formula:
- C23H19ClF3NO3
- IUPAC Name:
- Reaction mass of (R)-cyano(3-phenoxyphenyl)methyl rel-(1R,3R)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate and (R)-cyano(3-phenoxyphenyl)methyl rel-(1S,3S)-3-((1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropanecarboxylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill Ltd., Wyton, Huntingdon, Cambridgeshire, UK
- Weight at study initiation: 2.5-3.0 kg
- Housing: individually in aluminium sheet cages
- Diet (e.g. ad libitum): Labsure CRB ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: minimum 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-20°C
- Humidity (%): 50-60%
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: left flank: clipped; right flank: clipped and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL per application site (two application sites per flank)
- Duration of treatment / exposure:
- 24 h
- Observation period:
- at 24 and 72 h after start of application
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: left and right flank
- Type of wrap if used: the test item was covered by a surgical gauze patch, wrapped with a piece of rubber sheeting and secured with adhesive polyethylene tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with warm water
- Time after start of exposure: 24 h
SCORING SYSTEM:
Scoring was performed according to Draize (Erythema score 0-4, Edema score 0-4).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: intact skin, one animal was killed in extremis, three animals could not be evaluated du to brown stained skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 2 animals
- Time point:
- 72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: intact skin, one animal was killed in extremis
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 5 animals
- Time point:
- 24 h
- Score:
- 1.4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: intact skin, one animal was killed in extremis
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 5 animals
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: intact skin, one animal was killed in extremis
- Irritant / corrosive response data:
- Single application of cyhalothrin to rabbit skin caused brown staining which obscured erythema in three animals. In the remaining the test item caused only very slight or no erythema to both intact or abraded skin after 24h. After 72 h erythema had disappeared in all but one animal.
Edema were slight in all animals at 24 h and were fully reversible within 72 h. - Other effects:
- One animal showed severe signs of toxicity such as subdued appearance, piloerection, severe ataxia, and increased depth of respiration. This animal was killed in extremis at 18 h.
Clinical signs in the other animals included slight ataxia, increased depth of respiration, subdued appearance and increased abdominal tone.
Any other information on results incl. tables
Table 1: Individual animal data of rabbits treated with cyhalothrin (intact skin)
Animal No. |
Erythema |
Edema |
||||||
24 h |
72 h |
24 h |
72 h |
|||||
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
|
1 |
* |
* |
0 |
0 |
2 |
2 |
0 |
0 |
2 |
animal killed in extremis at 18 h due to severity of systemic effects |
|||||||
3 |
0 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
4 |
* |
* |
0 |
0 |
2 |
2 |
0 |
0 |
5 |
1 |
1 |
1 |
0 |
1 |
1 |
0 |
0 |
6 |
* |
* |
0 |
0 |
0 |
0 |
0 |
0 |
* Skin stained brown and obscured evaluation of erythema.
Table 2: Individual animal data of rabbits treated with cyhalothrin (abraded skin)
Animal No. |
Erythema |
Edema |
||||||
24 h |
72 h |
24 h |
72 h |
|||||
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
Patch 1 |
Patch 2 |
|
1 |
* |
* |
0 |
0 |
2 |
2 |
0 |
0 |
2 |
animal killed in extremis at 18 h due to severity of systemic effects |
|||||||
3 |
0 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
4 |
* |
* |
0 |
0 |
2 |
2 |
0 |
0 |
5 |
1 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
6 |
* |
* |
0 |
0 |
1 |
1 |
0 |
0 |
* Skin stained brown and obscured evaluation of erythema.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The study is considered to be reliable with restrictions.
- Executive summary:
Skin irritating properties of cyhalothrin were assessed in a Draize test similar to OECD Guideline 404 with slight deviations: 6 animals were used instead of 3, additionally to the clipped left flank the right flank was clipped and abraded with a scalpel, and two patches were applied per application site (left and right flank). GLP compliance was stated.
Single application of cyhalothrin to rabbit skin caused no or very slight erythema and very slight to slight edema to both intact and abraded skin at 24 h. Nearly all effects were fully reversible within 72 h. Mean erythema scores were 0.5 and 0.1 at 24 and 72 h, respectively. Corresponding edema scores were 1.4 and 0.0.
One animal showed severe signs of toxicity and was killed in extremis at 18 h. Clinical signs in the other animals included slight ataxia, increased depth of respiration, subdued appearance and increased abdominal tone.
Based upon the classification criteria according to the Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008, the test item has not to be classified as skin irritant.
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