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Diss Factsheets
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EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic plants other than algae
Administrative data
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a publication result with a scientific method.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Details on test material:
- no data
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test solutions
- Vehicle:
- no
- Details on test solutions:
- no data
Test organisms
- Test organisms (species):
- Lemna minor
- Details on test organisms:
- The plants were grown in open Erlenmeyer flasks in sterilized Steinberg medium (pH 5.5 ± 0.2) in a climate chamber with a constant temperature of 25 ± 2 °C.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
Test conditions
- Hardness:
- no data
- Test temperature:
- 25 ± 2 °C
- pH:
- 5.5± 0.2
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- To exclude pH effects on plant growth, pH was checked at the beginning and end of the test. The chamber was illuminated continuously with a maximum of 6000 lx. The assays were performed on six-well cell culture plates (Greiner Bio-One GmbH, Frickenhausen, Germany). The study was tested at least twice, with a minimum of six controls (pure Steinberg medium). The test started with one plant consisting of three duckweed fronds (leaves), and the measured endpoint was the inhibition of the growth rate determined by the frond area (mm2), which was calculated for the treated plants in relation to the untreated controls. The frond area was detected using a Scanalyzer from Lemnatec GmbH.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Dose descriptor:
- EC50
- Effect conc.:
- 0.46 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- no data
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- The confidence interval (a = 0.05) of the EC50 value was calculated using the R language. The dose-response curve parameters and plots were obtained using the drift package (version 0.05-92) for the R language and environment for statistical computing (www.r-pro- ject.org) as well as SigmaPlot Version 10.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 was 0.46 mg/l.
- Executive summary:
The growth inhibition assay with Lemna minor was performed according to a modified version of the test protocol described in detail by Drost et al. (2007). The EC50 was 0.46 mg/l.
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