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EC number: 252-328-0 | CAS number: 35037-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Five groups of 10 male and 10 female rats were exposed nose/head only to vapours of 4.5, 15.7, 22.5, 68.5, or 132 mg/m³ (analytical) 4-trifluoromethoxyphenyl isocyanate for 4 hours. The animals were observed for mortality, body weight and clinical signs up to day 21. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- p-(trifluoromethoxy)phenyl isocyanate
- EC Number:
- 252-328-0
- EC Name:
- p-(trifluoromethoxy)phenyl isocyanate
- Cas Number:
- 35037-73-1
- Molecular formula:
- C8H4F3NO2
- IUPAC Name:
- 1-isocyanato-4-(trifluoromethoxy)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 4.5, 15.7, 22.5, 68.5, or 132 mg/m³
- No. of animals per sex per dose:
- 10 male and 10 female rats/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 22.5 - 68.5 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- The animals which died intercurrent showed strong inflated, edematous, pale grey or dark red decolored lungs. Livers were pale and spotted., spleen and kidneys had a pale colour. The gastro-intestinal tract was filled with a reddish-mucous content.
- Body weight:
- Body weight gain was normal in males at 15.7 mg/m³.
Higher concentrations in males and all concentrations in females had a markedly influence on body weight. - Other findings:
- At a concentration of 15.7 mg/m³ air the rats showed an unspecific abnormal behaviour (lethargy, scruffy fur) and laboured breathing. up to 3 days after exposition. With higher concentrations these symptoms were present until death or termination of the study. Clear signs of irritation on the visible mucosa of the eyes and nose were evident.
Up to a concentration of 15.7 mg/m³ no evidence of organ damages were found.
Animals killed after the post-observation period had pale or greyish discoloured, inflated lungs on concentrations above 22.5 mg/m³
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Remarks:
- Based on EU GHS criteria
- Conclusions:
- Test item showed a strong irritating effect on the mucous membranes. The LC50 was 22.5 - 68.5 mg/m³ (0.0225 - 0.0685mg/L) for male and female rats.
- Executive summary:
Five groups of 10 male and 10 female rats were exposed nose/head only to vapours of 4.5, 15.7, 22.5, 68.5, or 132 mg/m³ (analytical) 4-trifluoromethoxyphenyl isocyanat for 4 hours. The animals were observed for mortality, body weight and clinical signs up to day 21. A gross pathological examination was performed on animals which died intercurrent or were killed after termination of the study.
4-trifluoromethoxyphenyl isocyanate showed a strong irritating effect on the mucous membranes. The LC50 was 22.5 - 68.5 mg/m³ (0.0225 - 0.0685mg/L) for male and female rats.
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