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EC number: 241-624-5 | CAS number: 17639-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was based on EEC methodology and performed at a reputable testing facility, however no information on GLP was provided in the test report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Report states study in accordance with EEC Methodology however no specific guideline was cited.
- GLP compliance:
- not specified
- Remarks:
- No information on GLP was provided in the test report.
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-Chloropropionic acid methyl ester.
- IUPAC Name:
- 2-Chloropropionic acid methyl ester.
- Details on test material:
- - Name of test material (as cited in study report): Methyl ACPA / 2-Chloropropionic acid methyl ester
- Physical state: Liquid
- Analytical purity: 99.4%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 2000 mg/kg/bw
- No. of animals per sex per dose:
- 2 animals per sex per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
Any other information on results incl. tables
A summary of the clinical signs observed during the course of the study is shown in Table 1.
Table1.
Signs |
No of rats in group showing signs |
|
Male |
Female |
|
Piloerection |
2/2 |
2/2 |
Hunched Posture |
2/2 |
2/2 |
Waddling gait |
2/2 |
2/2 |
Lethargy |
2/2 |
2/2 |
Pallor of the extremities |
2/2 |
2/2 |
Increased salivation |
2/2 |
2/2 |
Gasping/noisy respiration |
0/2 |
1/2 |
Unsteadiness |
2/2 |
2/2 |
Increased respiration |
2/2 |
2/2 |
Protruding eyes |
1/2 |
1/2 |
Temporary loss of hind limb function |
1/2 |
2/2 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The acute lethal oral dose of Methyl ACPA to rats was shown to be greater than 2000 mg/kg/bw.
- Executive summary:
The oral effect of Methyl-2-chloropropionate on rats was evaluated in a study in accordance with EEC methodology. Two male and two female Sprague-Dawley rats were dosed by oral gavage at 2000 mg/kg/bw. The animals were observed and clinical signs recorded for a period of 14 days after which the animals were sacrificed.
No deaths occurred. There was evidence of systemic toxicity in all animals which persisted throughout the study. Body weight gains were considered normal for this type of study. No abnormalities were evident at the macroscopic examination.
In conclusion, the acute lethal oral dose for Methyl-2-chloropropionate was shown to be > 2000 mg/kg/bw.
The toxicity end point for the oral route of exposure is above the 2000 mg/kg/bw threshold for classification under the CLP regulation; therefore no classification relating to oral toxicity is required.
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