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EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: Under the conditions of this study, the LD50 was greater than 2200 mg/kg body weight (males and females).
Acute dermal toxicity: Under the conditions of this study, the LD50 was greater than 2000 mg/kg body weight (males and females).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 200 mg/kg bw
- Quality of whole database:
- Two studies are available. The key study was performed in accordance with standardised guidelines and under GLP conditions and was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997). The quality of the database is therefore considered to be good.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Two studies are available. The key study was performed in accordance with standardised guidelines and under GLP conditions and was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997). The quality of the database is therefore considered to be good.
Additional information
Acute Oral Toxicity
The key study was conducted to investigate the acute oral toxicity of the test material in accordance with the standardised guidelines OECD 401 and EU Method B.1 under GLP conditions.
A group of ten fasted animals (five males and five females) was given a single oral dose of the test material prepared in olive oil DAB 9 at a dose level of 2200 mg/kg of bodyweight by gavage. Over a 14 day observation period, the animals were monitored for mortality, signs of toxicity and body weight gain. At the end of the observation period animals were sacrificed and subjected to necropsy with gross pathological examination.
No mortality occurred and no signs of toxicity were noted at this dose level. The expected body weight gains were observed throughout the course of the study. No abnormalities were noted at necropsy.
Under the conditions of this study, the LD50 was greater than 2200 mg/kg body weight (males and females).
In the supporting study, the potential of the test material to cause acute toxicity via the oral route was investigated in a limit test conducted using the rat. The study was awarded a reliability score of 4 in accordance with the criteria set forth by Klimisch et al. (1997).
Three male Fischer 344 rats received 2000 mg/kg of the undiluted test material by single dose oral gavage. Animals were monitored for body weight gain, in-life signs of toxicity and mortality for 14 days. At the end of the test, animals were subjected to necropsy.
No in-life signs of toxicity were observed in the rats. All rats survived and eventually gained body weight during the two week observation period. All tissues were within normal limits at necropsy.
Under the conditions of this study, the acute oral LD50 for male Fischer 344 rats was greater than 2000 mg/kg.
Acute Dermal Toxicity
The key study was conducted to investigate the acute dermal toxicity of the test material in accordance with the standardised guidelines OECD 402 and EU Method B.3 under GLP conditions.
The undiluted test material ground down to a fine dust was prepared on a compress moistened with water at a limit dose of 2000 mg/kg and then applied to the skin of 10 Sprague-Dawley rats (5 males and 5 females). The material remained on the skin for 24 hours under a semi-occlusive dressing.
Over a 14 day observation period, the animals were monitored for mortality, signs of toxicity and body weight gain. At the end of the observation period animals were sacrificed and subjected to necropsy.
The general behaviour and body weight gain of the animals were not affected by treatment. No deaths occurred at 2000 mg/kg. Macroscopic examination at the end of the study revealed no abnormalities.
Under the conditions of this study, the LD50 was greater than 2000 mg/kg body weight (males and females).
In the supporting study, the potential of the test material to cause acute toxicity via the dermal route was investigated in a limit test conducted using the rabbit. The study was awarded a reliability score of 4 in accordance with the criteria set forth by Klimisch et al. (1997).
Two female New Zealand White rabbits received a single 24 hour dermal application of 2000 mg/kg of the undiluted test material. Animals were monitored for body weight gain, in-life signs of toxicity and mortality for 14 days. At the end of the test, animals were subjected to necropsy.
No in-life signs of toxicity were observed in the rabbits. Dermal effects on the application sites included erythema, oedema, and, on one rabbit, a scab. All rabbits survived and gained body weight during the two week observation period. At necropsy, a scab was observed on the application site of one rabbit. Mucus, which was present in the colon of the same rabbit, was considered an incidental finding and not related to treatment. All other tissues were within normal limits.
Under the conditions of this study, the acute dermal LD50 for female New Zealand White rabbits was greater than 2000 mg/kg.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No 1272/2008, the substance does not require classification with respect to acute toxicity via the oral and dermal routes.
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