Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 411-950-4 | CAS number: 96562-58-2 DHPPME; MAK-ME; MEHPOPS; R-MAQ-ME
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
Description of key information
Campbell et al. (1993):Under the conditions of this study, the fat solubility of the test material was determined to be 82.57 g/kg HB307 standard fat.
Böck (1991): Under the conditions of this study, the solubility of the test material in standard fat is 9320 mg/100 g fat at 37 °C.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 9 320
- At the temperature of:
- 37 °C
Additional information
Two studies are available to address this endpoint and both are considered to be key as the data are equally reliable. The studies were assigned a reliability score of 1 in accordance with the criteria for assessing data quality set forth by Klimisch et al. (1997).
Campbell et al. (1993)
The fat solubility of the test material was investigated in accordance with the standardised guidelines OECD 116 and EU Method A.7 under GLP conditions.
Ten times the amount of the Saturation Mass Fraction of the test material as determined in the preliminary test was weighed into 8 flasks. To each flask, ca. 25 g of HB307 standard fat was accurately weighed. Four flasks were shaken at 30 °C and 4 at 50 °C in an orbital water bath. After 1 hour both groups were moved to a bath set at 37 °C and shaken further. Two flasks from each group were removed after 6 days and left to stand at 37 °C until sampled for analysis. An aliquot of the supernatant was removed, centrifuged and analysed. The remaining 2 flasks from both groups were shaken for a further 24 hours before removal from the orbital water bath, and treated in the same manner as the first set of samples.
Under the conditions of this study, the fat solubility of the test material was determined to be 82.57 g/kg HB307 standard fat.
Böck (1991)
The fat solubility of the test material was determined in accordance with the standardised guideline EU Method A.7 under GLP conditions.
UV spectrometry was used to determine the measured amount of test material compared to the weight amounts of the test material in chloroform following filtration of pre-saturated two phase solid-liquid mixtures of the test material and fat.
Under the conditions of this study, the solubility of the test material in standard fat is 9320 mg/100 g fat at 37 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
