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EC number: 473-690-8 | CAS number: 738602-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb - Jun 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 473-690-8
- EC Name:
- -
- Cas Number:
- 738602-93-2
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- (2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,5R)-4-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: sponsor, Batch 4G08
- Purity, including information on contaminants, isomers, etc.: Mixture of maltotriosyl glucoside and othe roligoglucosaccharides (approx. 95 %)
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature at about 20 °C, away from direct sunlight.
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions (e.g. in the exposure medium) and during storage: assumed stable
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: assumed stable
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: analytical determination of solubility/concentrations.
- Reactivity of the test material with the incubation material used (e.g. plastic ware): assumed stable
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- For the determination of the actual test item concentrations the following samples were taken:
Just before the start of the test: duplicate samples from the test medium, duplicate samples from the control
After 48 hours: duplicate samples from the test medium, duplicate from the control
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test medium was prepared by dissolving the test item completely in 500 mL of test water using intense stirring for ten minutes at room temperature.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The study was performed with young daphnids of a clone of the species Daphnia magna Straus. A clone of this species was originally supplied by the University of Sheffield/UK in 1992. Since that time, the clone has been bred in the laboratories of RCC in reconstituted water of the quality identical to the water quality used in the tests (in respect to pH, main ions, and total hardness) and under temperature and light conditions identical to those of the tests.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
Test conditions
- Hardness:
- 2.5 mmol/l
- Test temperature:
- 20 °C
- pH:
- 7.9
- Dissolved oxygen:
- 8.9 mg/L
- Nominal and measured concentrations:
- 100 mg/L nominal
The analytically determined test item concentration in the test medium at the start and the end of the test was 100 and 99 % of the nominal value. - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beaker
- Type (delete if not applicable): open (covered with glass plates)
- Material, size, headspace, fill volume: 100 mL, 50mL fill volume
- Volume of solution: 50 mL
- Aeration: the test water was aerated prior tothe start of the study until oxygen saturation was reached.
- Type of flow-through (e.g. peristaltic or proportional diluter): not applicable
- Renewal rate of test solution (frequency/flow rate): no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- No. of vessels per vehicle control (replicates): not applicable
- Biomass loading rate: not applicable
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted test water
- Total organic carbon: not measured
- Particulate matter: not measured
- Metals: not measured
- Pesticides: not measured
- Chlorine: not measured
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1
- Conductivity: not stated
- Salinity: not applicable
- Culture medium different from test medium: no
- Intervals of water quality measurement: at start and end
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light / 8 h dark
- Light intensity: between 570 and 750 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
mobility
- Reference substance (positive control):
- yes
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- For evaluation of the quality of the Daphnia magna clone and of the experimental conditions, potassium dichromate is tested as a positive control at least once a year to demonstrate satisfactory conditions of the test
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No toxicity was observed in Daphnia when treated with the test item at the limit dose of 100 mg/L. Therefore the NOEC is > 100 mg/L.
- Executive summary:
The acute toxicity of the test item MG-60 to Daphnia magna was determined in a 48 hour satic test according to the EU C.2 and OECD 202.
A limit test was performed in accordance with the EU Guideline to demonstrate that the test item has no toxic effect on the test organisms up to and including a nominal concentration of 100 mg/l. Thus, the only concentration tested was nominal 100 mg/L and control.
The analytically determined test item concentraiton in the test medium at the start and the end of the test was 100 and 99 % of thee nominal value. Under the conditions of the test, the test item MG-60 was stable during the test period of 48 hours. Therefore, all reported results are related to the nominal concentration of the test item.
In the control and at the test concentration of 100 mg/l, no immobilized test organisms were observed during the test period of 48 hours.
Therefore, the 48-hour NOEC and the 48-hour EC0 of MG-60 to Daphnia magna were determined to be at leas 100 mg/l. The 48 -hour NOEC and the 48-hour EC0 might even be higher but concentrations above 100 mg/l were not tested, according to EU Guideline. The 48-hour EC50 and the 48-hour EC100 were clearly higher than 100 mg/L. these values could not be quantified due to the absence of toxicity of MG-60 at the test concentration of 100 mg/L.
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