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Diss Factsheets
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EC number: 701-402-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-01-16 - 1992-07-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test substance FAT-80'001/I
Stability: guaranteed by the sponsor
Solubility: >50 g/l (in water)
Storage: room temperature
Appearance: liquid - Analytical monitoring:
- yes
- Details on sampling:
- ANALYTICAL CONTROL
Water samples were taken from the bath at the beginning and at the end of the experiment. - Vehicle:
- no
- Details on test solutions:
- Diluted In dechlorinated tap water (carbon filter)
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Test organism: Zebrafish (Brachidanio rerio)
Weight: 2.0 - 2.3 g
Length: 28 - 29 mm
Age: 83 days
Acclimatization: 12 days in dechlorinated tap water
Supplier: West Aquarium, Bad Lauterberg, BRD - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 179 mg/l CaCO3
- Test temperature:
- actual 21.9 - 22.9 °C ± 0.5 °C (nominal 21-25 °C within ± 1°C)
- pH:
- 7.7 - 8.3
- Dissolved oxygen:
- 79 - 85 %
- Nominal and measured concentrations:
- A pretest was carried out at 30,100, 300 and 1000 mg/l.
For the main test the concentrations were selected according to the results of the pretest as: 316, 562 and 1000 mg/l (nominal). - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 978 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality was seen throughout the study.
No abnormal responses of the test fish were observed.
The measured concentrations were in the range of 89.2-100.2 % of the nominal concentrations. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test item had no acute toxic effects on zebra fish under the present test conditions at a nominal concentration of 1000 mg/L.
- Executive summary:
DMPPA_701-402-5 was assessed for toxicity to fish in a 96 hour study conducted according to OECD Guideline 203. Based on the results of the pre-study, 4 groups of 10 Zebra fish each were exposed to test concentrations of 316, 562 and 1000 mg/L (nominal). No mortality was seen throughout the study and no abnormal responses of the test fish were observed. The measured concentrations were in the range of 89.2-100.2 % of the nominal concentrations. Based on the findings of the study, the LC50 was determined to be >1000 mg/L.
Reference
Description of key information
The acute aquatic toxicity of the test item was tested in a valid GLP study in accordance with EU Method C.1 by exposing zebra fish (Danio rerio) during 96 hours in a static test to a nominal concentration of 316, 562 and 1000 mg/L. No adverse effects were observed and the resulting LC50 value was >1000 mg/L. The above outcome was further supported by the finding of 48h LC50 to be 2750 mg/L in a supporting study conducted according to DIN 38412, Teil 15.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 000 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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