Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 435-080-1 | CAS number: 1070-64-0 6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8. Feb 2000 to 29. Feb 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl 6,8-dichlorooctanoate
- EC Number:
- 435-080-1
- EC Name:
- Ethyl 6,8-dichlorooctanoate
- Cas Number:
- 1070-64-0
- Molecular formula:
- C10H18Cl2O2
- IUPAC Name:
- ethyl 6,8-dichlorooctanoate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Batch: Ds 1099
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
- Preliminary study:
- Range finding with 3 animals of each sex:
Dose: 400/894/2000 mg/kg --> all animals survived
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 000
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- other: not substance related
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.
No mortality occurred.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex. - Executive summary:
No toxic effects of the test substance were noted in life at the dose of 2000 mg/kg body weight.
No mortality occurred.
The LD50 (dermal) of 6,8-Dichloroethylcaprylat is higher than 2000 mg/kg body weight in rats of either sex.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
