Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-329-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Sep - 03 Oct 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hessisches Ministerium für Umwelt, Klimaschutz, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
Test material
- Reference substance name:
- Carboxylic acids, di-, C5-9
- EC Number:
- 701-329-9
- Molecular formula:
- C5di: C5H8O4 C6di: C6H10O4 C7di: C7H12O4 C8di: C8H14O4 C9di: C9H16O4
- IUPAC Name:
- Carboxylic acids, di-, C5-9
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: from a domestic waste water treatment plant in Rossdorf, Germany
- Preparation of inoculum for exposure: deposited for 15 minutes, washed by centrifugation and liquid phase was decanted; 3 x procedure: re-suspension of solid material in test water and centrifuging; weighing, drying and determination of wet sludge/dry weight ratio of sludge suspension
- Pretreatment: overnight aeration
- Concentration of sludge: 3.5 g dry material/L
- Water filtered: no - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 102.5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 164.5 mg/L
- Based on:
- ThOD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to OECD 301 A
- Test temperature: 22 ± 1°C
- pH: 7.1 - 7.6
- Suspended solids concentration: 3.5 g/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: manometric test system with flasks containing approx. 500 mL
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: overnight aeration of sludge suspension
- Measuring equipment: BSB/BOD sensor system (O2 consumption calculated from pressure decrease in reaction vessel)
- Test performed in closed vessels due to significant volatility of test substance: gas-tight closed by a measuring head
- Details of trap for CO2 and volatile organics if used: Potassium hydroxide solution
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2
- Abiotic sterile control: 1
- Toxicity control: 1
- Other: procedure control: 1
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 87
- Sampling time:
- 28 d
- Details on results:
- Mean pass level of > 60% reached after on test day 9
BOD5 / COD results
- Results with reference substance:
- 75% degradation after 14 days and 78% degradation after 28 days
Any other information on results incl. tables
Table 1: Cumulative Biochemical Oxygen Demand (mg O2/L) in Test Flasks during the Test Period of 28 days.
Time (days) |
Test substance |
Inoculum control |
Procedure control |
Abiotic control |
Toxicity control |
||
|
|
|
|
||||
1 |
15 |
15 |
0 |
0 |
30 |
0 |
55 |
2 |
30 |
25 |
0 |
0 |
70 |
0 |
85 |
9 |
115 |
95 |
0 |
5 |
125 |
0 |
170 |
28 |
150 |
140 |
0 |
5 |
135 |
0 |
245 |
Table 2: % Degradation in Test Flasks during the Test Period of 28 days.
Time (days) |
Test substance |
Procedure control |
Toxicity control |
|
|
|
|||
1 |
9 |
9 |
18 |
16 |
2 |
18 |
15 |
41 |
25 |
9 |
68 |
56 |
72 |
50 |
11 |
71 |
63 |
72 |
57 |
28 |
89 |
84 |
78 |
72 |
Table 3: Validity criteria for OECD 301 F.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
Difference of extremes of replicate values of the removal of the test chemical at the plateau, at the end of the test or at the end of the 10-d window, as appropriate, is less than 20%. |
Difference of duplicate values at day 28 differed by 5% |
yes |
Percentage degradation of the reference compound reached the pass level by day 14 (≥ 60%). |
> 60% after 4 days |
yes |
The toxicity control should degrade to at least 35% (based on DOC) or at least 25% (based on ThOD or ThCO2) within 14 d. |
64% at day 14 |
yes |
The oxygen uptake of the inoculum blank is normally 20-30 mg O2/L and should not be greater than 60 mg/L in 28 days. |
2.5 mg O2/L after 28 days |
yes |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
- Interpretation of results:
- readily biodegradable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.