5-acetyl-10,11-dihydro-3-nitro-5H-dibenz[b,f]azepine

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See QMRF). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Specific details on test material used for the study:

O=C(N1C2=CC=CC=C2CCC3=C1C=C([N+]([O-])=O)C=C3)C

Test organisms (species):

other: Fish

Dose descriptor:

LC50

Effect conc.:

> 10 - <= 100 mg/L

Conc. based on:

test mat.

Sublethal observations / clinical signs:

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Conclusions:

The LC50 of the substance was predicted to be Toxic, category 3.