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EC number: 272-897-9 | CAS number: 68919-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Remarks:
- measured as Critical Micellization Concentration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 06, 2018 - May 3rd, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The Critical Micellization Concentration is defined as the concentration of surfactants above which micelles form and all additional surfactants added to the system go to micelles. This concentration is determined by measuring the surface tension of solutions at different concentrations. The surface tension consists in a measurement of the maximum vertical force necessary to separate a ring from its contact with the surface of the liquid being examined. These measurements are performed in a thermo-regulated cup at the requested temperature, which is 20.0°C ± 1.0°C. The surface tension is defined as the free surface enthalpy per unit of surface and is expressed in mN/m.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: surface tension measurement
- Key result
- Water solubility:
- 17 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 3.9 - <= 4.1
- Conclusions:
- The Critical Micellization Concentration of the test item was determined to be 17.0 mg/L at 20.0 °C ± 1.0 °C.
- Executive summary:
The Critical Micellization Concentration (CMC) of the test item was determined in a GLP-compliant study by measuring the surface tension of test item solutions at different test item concentrations. The CMC of the test item was 17.0 mg/L at 20.0 °C ± 1.0 °C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 18, 2018 - March 14, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 205 g/L
- Conc. based on:
- test mat.
- Remarks:
- determined from the quantitative analysis of C12 amphopropionic acid
- Temp.:
- 20 °C
- pH:
- >= 3.9 - <= 4.2
- Key result
- Water solubility:
- >= 202 g/L
- Conc. based on:
- test mat.
- Remarks:
- determined from the quantitative analysis of acrylic acid
- Temp.:
- 20 °C
- pH:
- >= 3.9 - <= 4.2
- Conclusions:
- The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
- Executive summary:
The water solubility of the test item was investigated in a GLP-compliant study performed in accordance with EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
Referenceopen allclose all
PRELIMINARY TEST
Through the serial volume addition of water to the test item, the following table shows the solubility in water of the test item at 20.0 °C ± 2.0 °C.
Weight of the test item (g) | Volume of water (mL) | Solubility* (g/L) | |
0.11179 | 0.1 | No | / |
0.5 | No | / | |
1 | No | / | |
2 | No | / | |
10 | Yes | 10-50 |
*Solubility:
No: Undissolved material was visually observable in the test solution.
Yes: No undissolved material was visually observable in the test solution.
Description of key information
The water solubility of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with EU Method A.6 (Water Solubility) and OECD Guideline 105 (Water Solubility). The water solubility of the test item at 20.0°C ± 2.0°C was determined to be ≥ 202-205 g/L from the quantitative analysis in the test solutions of its main constituents, C12 amphopropionic acid and acrylic acid.
In addition, the Critical Micellization Concentration (CMC) of the test item was determined in a GLP-compliant study (Demangel, 2019) by measuring the surface tension of solutions at different concentrations. The CMC of the test item was 17.0 mg/L at 20.0 °C ± 1.0 °C.
Key value for chemical safety assessment
- Water solubility:
- 202 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was investigated in a GLP-compliant study (Ricau, 2019) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.
In addition, the Critical Micellization Concentration (CMC) of the test item was investigated in a GLP-compliant study (Demangel, 2019) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was also selected as key study for the endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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