Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 946-365-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1995/09/20-1995/10/04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD Guideline 403 - GLP
- Justification for type of information:
- Hydrocarbons, C9-C10, aromatics, >1% Naphthalene are a combination of Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12 Aromatics. Read across data is available for Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12 Aromatics and the worst case scenario for each end point has been presented.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1995/09/20-1995/10/04
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Similar to OECD Guideline 403 - GLP
- Justification for type of information:
- Hydrocarbons, C9-C10, aromatics, >1% Naphthalene are a combination of Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12 Aromatics. Read across data is available for Hydrocarbons, C9 Aromatics and Hydrocarbons, C10-C12 Aromatics and the worst case scenario for each end point has been presented.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4 778 mg/m³ air (analytical)
- Mortality:
- One male animal was found dead on day 2 post-exposure. This animal was observed as prostrate with wet fur, oral and nasal discharge, wet rales, and little sign of stool or food consumption.
- Clinical signs:
- other: The majority of abnormalities were noted during the first 2 days of the 14 day observational period. These abnormalities included wet/matted fur, oral/nasal discharge, reddening of the eyelids and extremities, anogenital staining, and alopecia.
- Body weight:
- All animals gained body weight over their initial values.
- Gross pathology:
- A dead animal was observed with dark red nasal turbinates and bright red lungs, red material in the stomach mixed with ingesta, wet/matted fur, and nasal discharge. Surviving animals were observed having small seminal vesicles, scabs, red foci in the lungs and thymus. One male and all five females were free of abnormalities.
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 is >4.778 mg/L for aerosolized MRD-95-246.
Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations. - Executive summary:
This data is being read across from the source study that tested Hydrocarbons, C10-C13, aromatics, >1% naphthalene based on analogue read across.
Five male and five female rats were exposed to 4778 mg/m3 (4.778 mg/L, analytical)/ 11321 mg/m3 (11.3 mg/L, nominal) aerosol of test material MRD-95-246 for 4 hours. Animals were observed for 14 days.
One male animal was found dead on day 2 post-exposure. The majority of abnormalities were noted during the first 2 days of the 14 day observational period. These abnormalities included wet/matted fur, oral/nasal discharge, reddening of the eyelids and extremities, anogenital staining, and alopecia. One male and all five females were free of abnormalities by day 14 and surviving animals continued to gain weight through day 14.
The LC50 is >4.778 mg/L for aerosolized MRD-95-246.
Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hydrocarbons, C10-C13, aromatics, >1% naphthalene
- EC Number:
- 926-273-4
- Molecular formula:
- None available - not a single isomer - see remarks
- IUPAC Name:
- Hydrocarbons, C10-C13, aromatics, >1% naphthalene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CDBR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Source: Charles River Laboratories Inc.
Sex: Male (5), Female (5) for each species
Age at study initiation: 7 weeks
Weight at study initiation:
Males: 145-171g
Females: 146 - 177g
Housing: Single housed
Diet (e.g. ad libitum): PMI Feeds, Inc. Certified Rodent Diet #5002 ad libitum during non-exposure period; withheld during exposure
Water (e.g. ad libitum): automatic watering system, ad libitum
Acclimation period: 7d and animals were examined once a day for viability
ENVIRONMENTAL CONDITIONS
Temperature (°F): 68-76
Humidity (%): 40-70%
Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test material was generated using a single barrel Laskin nebulizer. Compressed air was supplied to the nebulizer at 5-7 psi back pressure, producing a droplet aerosol that was mixed with room air and drawn into the exposure chamber. Particle size was determined via a Sierra Instruments Model 210 Cascade Impactor. DATA: Exposure Concentration (average actual): 4778 mg/m3
Exposure Concentration (nominal): 11321 mg/m3
Chamber Size: 150L
ATM Pressure: slightly negative pressure to the room
Temperature: 25°C
Air Flow Rate: 30 (L/min) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically (aerosol), GC/FID (vapour)
- Duration of exposure:
- 4 h
- Concentrations:
- 4778 mg/m3 (analytical)
11321 mg/m3 (nominal))
Chamber Size: 150L
ATM Pressure: slightly negative pressure to the room
Temperature: 25°C
Air Flow Rate: 30 (L/min) - No. of animals per sex per dose:
- Male (5), Female (5) for each species
- Control animals:
- no
- Details on study design:
- The animals were individually housed in a 150L stainless steel whole body inhalation chamber that was under a slight negative pressure to the room and had an air flow of 30 L/min. The exposure was 4 hours plus equilibration time (~23 min) and air flow, temperature, and humidity were continuously monitored. Animals were observed for mortality and obvious toxic signs at 15 min intervals for the first hour of exposure and then once each hour until the termination of the exposure. Body weights for each animal were recorded prior to exposure and on days 7 and 14. A gross necropsy was performed on every animal.
- Statistics:
- Mean and Standard Deviation of body weight and body weight change by group and sex.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4 778 mg/m³ air (analytical)
- Mortality:
- One male animal was found dead on day 2 post-exposure. This animal was observed as prostrate with wet fur, oral and nasal discharge, wet rales, and little sign of stool or food consumption.
- Clinical signs:
- other: The majority of abnormalities were noted during the first 2 days of the 14 day observational period. These abnormalities included wet/matted fur, oral/nasal discharge, reddening of the eyelids and extremities, anogenital staining, and alopecia.
- Body weight:
- All animals gained body weight over their initial values.
- Gross pathology:
- A dead animal was observed with dark red nasal turbinates and bright red lungs, red material in the stomach mixed with ingesta, wet/matted fur, and nasal discharge. Surviving animals were observed having small seminal vesicles, scabs, red foci in the lungs and thymus. One male and all five females were free of abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The LC50 is >4.778 mg/L for aerosolized MRD-95-246.
Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations. - Executive summary:
Five male and five female rats were exposed to 4778 mg/m3 (4.778 mg/L, analytical)/ 11321 mg/m3 (11.3 mg/L, nominal) aerosol of test material MRD-95-246 for 4 hours. Animals were observed for 14 days.
One male animal was found dead on day 2 post-exposure. The majority of abnormalities were noted during the first 2 days of the 14 day observational period. These abnormalities included wet/matted fur, oral/nasal discharge, reddening of the eyelids and extremities, anogenital staining, and alopecia. One male and all five females were free of abnormalities by day 14 and surviving animals continued to gain weight through day 14.
The LC50 is >4.778 mg/L for aerosolized MRD-95-246.
Classification as an acute inhalation toxicant is not warranted under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) or under Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)