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Diss Factsheets
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EC number: 212-850-1 | CAS number: 873-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- other: Incident report
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from incident report according to HAZOP, no effect concentration available
Cross-reference
- Reason / purpose for cross-reference:
- exposure-related information
Reference
- Name:
- T002680
- Implementation:
- EU
- Type of classification:
- self-classification
- Related composition:
- T002680
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- hazard class not assessed
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Hazard category:
- Acute Tox. 4
- Hazard statement:
- H302: Harmful if swallowed.
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H311: Toxic in contact with skin.
- Hazard category:
- Acute Tox. 3
- Hazard statement:
- H331: Toxic if inhaled.
- Reason for no classification:
- data conclusive but not sufficient for classification
- Hazard category:
- Eye Irrit. 2
- Hazard statement:
- H319: Causes serious eye irritation.
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Reason for no classification:
- data lacking
- Hazard category:
- Muta. 2
- Hazard statement:
- H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Reason for no classification:
- data lacking
- Reason for no classification:
- data conclusive but not sufficient for classification
- Hazard category:
- Aquatic Chronic 3
- Hazard statement:
- H412: Harmful to aquatic life with long lasting effects.
- Reason for no classification:
- data lacking
- Signal word:
- Warning
- Code:
- GHS07: exclamation mark
- Code:
- GHS06: skull and crossbones
- Code:
- GHS08: health hazard
- Hazard statement:
- H302: Harmful if swallowed.
- Hazard statement:
- H311: Toxic in contact with skin.
- Hazard statement:
- H331: Toxic if inhaled.
- Hazard statement:
- H319: Causes serious eye irritation.
- Hazard statement:
- H341: Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
- Hazard statement:
- H412: Harmful to aquatic life with long lasting effects.
- Precautionary statement:
- P284: [In case of inadequate ventilation] wear respiratory protection.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Expert judgement in allignment with HAZOP
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-aminobenzonitrile
- EC Number:
- 212-850-1
- EC Name:
- 4-aminobenzonitrile
- Cas Number:
- 873-74-5
- Molecular formula:
- C7H6N2
- IUPAC Name:
- 4-aminobenzonitrile
Constituent 1
Results and discussion
Any other information on results incl. tables
At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.
The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact (see justification statement attached to this study summary).
After the incidents, required PPE was improved leading to safe conditions.
Applicant's summary and conclusion
- Conclusions:
- At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.
The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact.
After the incidents, required PPE was improved leading to safe conditions. - Executive summary:
At the production site have been a lownumber of incidents where workers suffered from symptoms of cyanosis after they were exposed to 4 -aminobenzonitrile while cleaning a vessel of filling substance to packaging. At that time, workers used Personal Protective Equipments (PPE) but PPE wasn't at the necessary standard and hygiene was low. Dermal and inhalation exposure could have been possible.
The symptoms led to the conclusion that in contrast to studies, the substance should be classified as "toxic" for inhalation and skin contact.
After the incidents, required PPE was improved leading to safe conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.