Registration Dossier
Registration Dossier
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EC number: 236-415-0 | CAS number: 13360-63-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-01-01
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Method: other: in analogy to OECD Guide-line 401
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butyl(ethyl)amine
- EC Number:
- 236-415-0
- EC Name:
- Butyl(ethyl)amine
- Cas Number:
- 13360-63-9
- Molecular formula:
- C6H15N
- IUPAC Name:
- butyl(ethyl)amine
- Details on test material:
- - Name of test material (as cited in study report): N-Ethyl-N-Butylamine [CAS No. 13360-63-9], not further specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: arachis oil
- Doses:
- 200; 271; 368; 500; 679 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 467 mg/kg bw
- 95% CL:
- 397 - 549
Any other information on results incl. tables
Mortality (day 14)
Dose (mg/kg bw) |
Males |
Females |
200 |
0/5 |
0/5 |
271 |
0/5 |
0/5 |
368 |
2/5 |
1/5 |
500 |
2/5 |
3/5 |
679 |
5/5 |
4/5 |
Applicant's summary and conclusion
- Executive summary:
The acute oral toxicity of Ethylbutylamine was examined in rats (5/sex and dose; dose levels 200, 271, 368, 500, and 679 mg/kg bw. Test material was administered as an emulsion (50% in arachis oil) by oral gavage. The study was conducted similar to OECD TG 401 and under GLP conditions. The purity of the test material was not reported.
Mortalities occurred within one day after dosing in groups at 368 mg/kg bw and above. The LD50was 467 mg/kg bw in this study (Safepharm, 1982).
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