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EC number: 285-089-6 | CAS number: 85029-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The submission substance produced slight skin and eye irritation in reliable in vivo studies, not severe enough to require classification.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Origin: HOECHST AG, Kastengrund, conventional breed
Body weights: 3.4 - 3.9 kg
Age: approx. 3-5 months - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml of pure substance
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- The animals were assessed at 30 min, 60 min, 24 h, 48 h and 72 h after exposure.
- Number of animals:
- 3
- Details on study design:
- Approximately 24 h before test start, the three test animals were clipped in an area of 25 cm² in the dorsal region with an electric clipper. Only animals with intact skin were used for the test. Each animal was treated with 0.5 ml pure test substance on the prepared skin area which was then covered with a 2.5 x 2.5 cm gauze patch then. The test site was then covered with a semi-occlusive dressing. The exposure time was 4 hours. After exposure, the patch was removed and the treated area washed with lukewarm water to remove the test substance from the skin. The treated skin was examined 30 min, 60 min, 24 h, 48 h and 72 h after removal of the patch for erythema, oedema or incrustation of the skin and scored, respectively.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 0.3
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- Very slight erythema and oedema were observed 1 and 24 h after removal of the patch. However, these observations were reversible 48 h after removal of the patch.
- Interpretation of results:
- other: not irritant to skin
- Conclusions:
- The test substance is not irritating to skin.
- Executive summary:
The skin irritation / corrosion properties of the test substance was assessed in an in vivo skin irritation study with rabbits. As a result of the study, the test substance is not irritating to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Origin: HOECHST AG, Kastengrund, conventional breed
Body weights: 3.5 - 4.0 kg
Age: approx. 3 - 5 months - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml per eye
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- The eyes were examined at 1h, 24 h, 48 h and 72 h after application of the test substance.
- Number of animals or in vitro replicates:
- 3 animals
- Details on study design:
- Approximately 24 h before study start the eyes intended for treatment with the test substance were assessed after application of one drop of a 0.01 % sodium fluoresceine solution into the eye under UV light for damages of the cornea. Only animals with eyes without damages of the cornea were used for the study.
Each of the 3 animals was treated on the left eye's conjunctivae with 0.1 ml of test substance. The untreated right eye was used as control. The treated eyes were rinsed thoroughly with physiological saline solution (at 37 °C) 24 h after the application of the test substance and at each timepoint when the treated eyes showed secretion or when the cornea was assessed with sodium fluoresceine solution.
The treated eyes were assessed 1 h, 24 h, 48 h and 72 h after application of the test substance. At the 24 h and 72 h assessments, the cornea was assessed for damages as well after instillation of 0.01 % sodium fluoresceine solution under UV light. Damages to the cornea, iris and conjunctiva was assessed and scored numerically.. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- After 1 hour of the test substance application, the conjunctivae of the animals were coloured diffuse karmesin red to strong red and slightly swollen. In addition, clear and colorless secretion occurred. After one day after application, clear hyperemia of the conjunctivae blood vessels were observed. However, on day 2 after application of the test substance, all irritation signs were reversible.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not eye-irritating.
- Executive summary:
The eye irritation potential of the test substance was assessed in a study according to OECD guideline 405 in rabbits. As a result of the study, the substance showed to be not irritating to the eye.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the skin irritation study, very slight erythema and oedema were observed 1 and 24 h after removal of the patch. However, these observations were reversible 48 h after removal of the patch.
In the eye irritation study, the conjunctivae of the animals were coloured diffuse karmesin red to strong red and slightly swollen 1 h after application. In addition, clear and colorless secretion occurred. After one day after application, clear hyperemia of the conjunctivae blood vessels were observed. However, on day 2 after application of the test substance, all irritation signs were reversible and scores were below the critical values for classification.
Justification for classification or non-classification
Slight skin and eye irritation was observed, not severe enough to require classification according to Regulation (EC) No. 1272/2008 (CLP).
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