Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 239-914-1 | CAS number: 15816-71-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral application by gavage, undiluted test substance., 5 doses, observation time 14 days, determination of signs of intoxication, stat.method:probit analysis.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose: number of dead animals (time of death)// number of rats with symptoms 0.16 ml/kg bw: 0/10 (-) // 10/10 0.18 ml/kg bw: 1/10 (3h) // 10/10 0.20 ml/kg bw: 5/10 (3h) // 10/10 0.25 ml/kg bw: 7/10 (3h) // 10/100.30 ml/kg bw: 10/10 (2h-2d) // 10/10
- Clinical signs:
- tonical cramps, sedation, poor general condition
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral toxicity of dicyclohexylamine was evaluated in male Wistar rats. The test substnace was administered oral by gavage at doses of 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw to groups of 10 male animals. Signs of intoxication were tonical cramps, sedation, poor general condition. The LD50 was estimated as 200 mg/kg bw.
- Executive summary:
The acute oral toxicity of dicyclohexylamine was evaluated in male Wistar rats. The test substnace was administered oral by gavage at doses of 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw to groups of 10 male animals. Signs of intoxication were tonical cramps, sedation, poor general condition. The LD50 was estimated as 200 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
