Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 239-914-1 | CAS number: 15816-71-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Sufficient information to take into account for evaluation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Die Untersuchung des Verhaltens von Cyclohexylamin (CHA) und Dicyclohexylamin (DCHA) im Koerper
- Author:
- Filov VA
- Year:
- 1 968
- Bibliographic source:
- Gig. Tr. prof. Zabol. 7, 29-33
Materials and methods
- Objective of study:
- absorption
- excretion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 2 rats were exposed to vapor; then amine concentration in blood was determined
- GLP compliance:
- no
Test material
- Reference substance name:
- Dicyclohexylamine
- EC Number:
- 202-980-7
- EC Name:
- Dicyclohexylamine
- Cas Number:
- 101-83-7
- Molecular formula:
- C12H23N
- Test material form:
- not specified
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- 80 minutes
Doses / concentrations
- Remarks:
- doses not specified
- No. of animals per sex per dose / concentration:
- 2
Results and discussion
Main ADME results
- Type:
- absorption
- Results:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- 0.014 and 0.026 mg DCHA/ml blood were determined indicating that dicyclohexylamine penetrate the alveolar membrane and enter the blood.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Inhalation exposure (concentration not given) for 80 minutes resulted in 0.014 and 0.026 mg dicyclohexylamine /ml blood, respectively, indicating that dicyclohexylamine penetrates the alveolar membranes and enters the blood.
- Executive summary:
Inhalation exposure (concentration not given) for 80 minutes resulted in 0.014 and 0.026 mg dicyclohexylamine /ml blood, respectively, indicating that dicyclohexylamine penetrates the alveolar membranes and enters the blood.
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