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EC number: 619-536-7 | CAS number: 68425-57-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test item was tested for its acute skin irritation on the shaved back skin of three rabbits in an OECD 404 study. Based on the results of the study the substance is classifed as corrosive to the skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Name: Phosphoric acid, mixed decyl and octyl esters, compds. with diethanolamine (Phosphorsaeure (C8-C10-Alkyl)-ester, DEA-Salz)
CAS No.: 68425-57-0 (68186-45-8)
Physical state: white solid at 20 °C (turbid, non-pourable paste) - Species:
- rabbit
- Strain:
- other: Kleinrussen, Chbb:HM
- Details on test animals or test system and environmental conditions:
- Test animals:
Species/strain: rabbits, healthy Kleinrussen, Chbb:HM
Source: Fa. Thomae, Germany
Sex: male
Mean body weight at the beginning of the study: ca. 2460 g
Age at the beginning of the study: 15 months
Number of animals: 3
Housing and Feeding Conditions:
- Temperature: 20 - 25 °C
- Relative humidity: 45 - 70%
- Artificial light, sequence being 12 hours light, 12 hours dark
- Air change: not specified
- Free access to Altromin-Haltungsdiät 2023
- Free access to tap water (drinking water)
- single-housed animals
- Adequate acclimatisation period (at least 1 week) under laboratory conditions - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Semiocclusive dressing (gauze dressing) of 6 cm2 loaded with 0.5 g test material.
- Duration of treatment / exposure:
- The exposure of the test animals was 4h.
- Observation period:
- The obervation period of the test animals was 21d.
- Number of animals:
- Three male rabbits were used as test animals.
- Details on study design:
- The test item was tested for its acute skin irritation on the shaved back skin of three rabbits (Kleinrussen, Chbb:HM). The contact time under semiocclusive conditions amounts to four hours. [Method: Off. J. Europ. Commun. L 251, 27, 106-108 (1984) and OECD-Guidelines for Testing of Chemicals No 404].
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 1
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- other: 1 h
- Score:
- 3
- Max. score:
- 3
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 24 h
- Score:
- 1.67
- Max. score:
- 2
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 48 h
- Score:
- 2.67
- Max. score:
- 3
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 3
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 72 h
- Score:
- 3.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 72 h
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 d
- Remarks:
- Eschar and scar formation in two of three test animals after 21 d.
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 24/48/72 h
- Score:
- >= 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- three animals
- Time point:
- 24/48/72 h
- Score:
- >= 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- positive indication of irritation
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- The test item was tested for its acute skin irritation on the shaved back skin of three rabbits in an OECD 404 study. Based on the results of the study the substance is classified as corrosive to the skin.
- Executive summary:
The test item was tested for its acute skin irritation on the shaved back skin of three rabbits (Kleinrussen, Chbb:HM). The contact time under semiocclusive conditions amounts to four hours. [Method: Off. J. Europ. Commun. L 251, 27, 106-108 (1984) and OECD-Guidelines for Testing of Chemicals No 404]. Strong erythema and edema were observed 1-72 hours after the exposition. At two animals scarring was observed at the application side 21 days after the exposure. The substance is classified as corrosive to the skin.
Reference
Results
The test item was tested for its acute skin irritation on the shaved back skin of three rabbits (Kleinrussen, Chbb:HM). The contact time under semiocclusive conditions amounts to four hours. [Method: Off. J. Europ. Commun. L 251, 27, 106-108 (1984) and OECD-Guidelines for Testing of Chemicals No 404]. Strong erythema and edema were observed 1-72 hours after the exposition. At two animals scarring was observed at the application side 21 days after the exposure. The substance is classified as corrosive to the skin.
Table1 : Symptoms
Skin reactions | mean value (24/48/72 h) | number of animals |
Erythema |
>= 2 | 3 |
Oedema |
>= 2 | 3 |
Scar formation was observed in two animals after a 21d observation period.
Table 2: Assessment of skin reactions
Animal No. | Hours after exposure [h] | |||||||
1 | 24 | 48 | 72 | |||||
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
|
1 | 1 | 3 b | 2 | 4 n e | 3 | 3 n e | 4 | 3 n e |
2 | 1 | 3 b | 2 | 2 n e | 3 | 3 n e | 4 | 2 n e |
3 | 1 | 3 b | 1 | 3 n e | 2 | 3 n e | 3 | 2 n e |
b = brownish discoloration of skin
n = necrosis
e = eschar formation
Table 3: Assessment of skin reactions
Animal No. | Days after exposure [d] | ||||
7 | 14 | 21 | 21 | ||
reversibility | reversibility | reversibility | Erythema |
Oedema |
|
1 | no | no | no | 0 | 0 s e |
2 | no | no | no | 0 | 0 s e |
3 | no | no | yes | 0 | 0 |
e = eschar foramtion
s = scar formation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study need not be conducted because the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
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