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Diss Factsheets
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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: The undiluted test substance was applied to the clipped intact shaven skin of five male albino rabbits. The application sites were covered with impervious cuffs for a period of 24 h, after which the cuffs were removed. Clinical observations at 24 h after dosing and daily thereafter for 14 days. Body weights at 0 and 14 days. Necropsy on found dead and on survivors at day 14.
- Short description of test conditions: 24 h exposure on 5 animals
- Parameters analysed / observed: Mortality, and clinical observations, body weights and necropsy - GLP compliance:
- no
- Remarks:
- The study has been conducted in 1976 before the implementation of the Good Laboratory Practice. However, it follows the scientific procedures in force at that time, is well documented and raw data is available.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: Amber liquid
- Details on test material:
- - Name of test material (as cited in study report): Kathon™ 886 all magnesium formulation
- Physical state: Amber liquid
- Stability under test conditions: stable at room temperature
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 0098
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: No
- Final dilution of a dissolved solid, stock liquid or gel: Undiluted
OTHER SPECIFICS: Purity of test material was 13.2%
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: Adult
- Weight at study initiation: Range of weight: 246-261 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Clipped intact shaven skin, back of each animal
- Type of wrap if used: Occlusion with an impervious cuff
REMOVAL OF TEST SUBSTANCE
Not described in report
TEST MATERIAL
- Amount(s) applied: Kathon™ 886 was applied undiluted at doses of 313, 625, 1250 and 2500 mg/kg. - Duration of exposure:
- 24 hours
- Doses:
- 313, 625, 1250 and 2500 mg/kg.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations at 24 h after dosing and daily thereafter for 14 days. Body weights at 0 and 14 days.
- Necropsy of survivors performed: yes - Statistics:
- n/a
Results and discussion
- Preliminary study:
- n/a
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 660 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 370 - 1 210
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 87.12 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- n/a
- Clinical signs:
- other: Clinical signs were observed in dose levels up to and including 1250 mg/kg. However, rabbits in the 2500 mg/kg dose group appeared to have died prior to the recording of the first clinical observations. Clinical signs observed included: lethargy, prostrat
- Gross pathology:
- Necropsy of the decedents and survivors revealed only subcutaneous tissue damage at the application site.
- Other findings:
- n/a
Any other information on results incl. tables
Dose (mg/kg) |
Number of dead /number of investigated |
Time of death (range) |
Observations |
|
313 |
0/5 |
no deaths |
|
|
625 |
2/5 |
2 at 24 h |
|
|
1250 |
5/5 |
4 at 24 h; 1 at 48 h |
|
|
2500 |
5/5 |
5 at 24 h |
|
|
LD50value |
LD50was determined to be 660 mg/kg.
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Skin irritation consisted of severe erythema and edema followed by eschar formation. LD50 was determined to be 660 mg KathonTM 886/kg bw with 95% confidence limits of 370 and 1210 mg/kg. This corresponds to LD50 = 87.12 mg/kg a.i. (pure CMIT/MIT).
- Executive summary:
- The undiluted test substance was applied
to the clipped intact shaven skin of five male albino rabbits. The
application sites were covered with impervious cuffs for a period of 24 h,
after which the cuffs were removed. Clinical signs were
observed in dose levels up to and including 1250 mg/kg. However, rabbits
in the 2500 mg/kg dose group appeared to have died prior to the recording
of the first clinical observations. Clinical signs observed included:
lethargy, prostration, ataxia, dilation of pupils, hypothermia, slow
respiration and poor food consumption.Skin
irritation consisted of severe erythema and edema followed by eschar
formation.LD50was
determined to be 660 mg Kathon 886/kg bw with 95% confidence limits of 370
and 1210 mg/kg. This corresponds to LD50= 87.12 mg/kg a.i.
(pure CMIT/MIT).
According to Annex VI of Directive 67/548/EEC, CMIT/MIT should be classified as Toxic in contact with skin (R24) and assigned the symbol T by a single dermal administation (i.e., the acute dermal LD50is between 50 and 400 mg/kg bw in rats).
The technical grade Kathon 886F should be classified as harmful in contact with skin (R21) and assigned the symbol Xn by a single dermal administation (i.e., the acute oral LD50 is between 400 and 2000 mg/kg bw in rats)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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