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Diss Factsheets
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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 457 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1.23 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 660 mg/kg bw
Additional information
The acute toxicity studies were conducted on active substance as manufactured ACTICIDE®14 (Thor) and KathonTM886F (Dow) or on C(M)IT/MIT formulations (Kathon TM886 all magnesium formulations which is considered as equivalent to the technical grade Kathon™ 886F). The results, expressed as a C(M)IT/MIT active ingredient basis are presented in the table 3.2-1.
The acute oral LD50 of C(M)IT/MIT in rats ranges from 457 to 472 mg/kg bw (corr. to 64 to 66 mg a.i./kg bw). Dead animals show effects on stomach and intestines which are consistent with the corrosive properties of C(M)IT/MIT. Therefore, C(M)IT/MIT meets the EU criteria for
classification as ‘Harmful if swallowed’ and should be classified as Xn; R22 (corr. to ‘Toxic if swallowed’, R25 for C(M)IT/MIT 3:1) according to the directive 67/548/EC. A classification as Acute Tox 4 / H302: Harmful if swallowed is required according to the regulation 1272/2008/EC (corr. to Acute Tox. 3 /H 301: Toxic if swallowed for C(M)IT/MIT 3:1).
The acute dermal LD50 of KathonTM886 (A6.1.2/01) in male rabbits was 660 mg/kg (corr. to 87 mg a.i/kg bw). In rats (A6.1.2/01), the acute dermal LD50 of ACTICIDE 14 was > 1008 mg/kg (corr. to 141 mg a.i/kg b.w). Observed effects are restricted to local effects or are subsequent to local effects. C(M)IT/MIT should be classified ‘Xn; R21 ‘Harmful in contact with skin’ according to the EU criteria for classification (corr. to ‘Toxic in contact with skin’, R24 for C(M)IT/MIT 3:1) according to the directive 67/548/EC. A classification as Acute Tox 3 / H312: Harmful in contact with skin is required according to the regulation 1272/2008/EC (corr. to Acute tox 2 / H 310: Fatal in contact with skin for C(M)IT/MIT 3:1) .
After acute exposure by inhalation, C(M)IT/MIT induces effects in relation with its corrosive properties. The 4-hr nose-only acute inhalation LC50 of C(M)IT/MIT in rats ranges from 1.23 to 2.36 mg/L air (corr. to 0.171 to 0.33 mg a.i./L air). The effects observed are consistent with the clinical signs of respiratory irritation. It is likely that the deaths resulted from excess fluids in the respiratory tract due to the irritant/corrosive nature of C(M)IT/MIT. It is proposed to adopt the classification Xn; R20 ‘Harmful by inhalation” based on the studies from Dow and Thor (corr. to T+;R26 ‘Very toxic by inhalation’ for C(M)IT/MIT 3:1) according to the directive 67/548/EC. A classification as Acute Tox 4 / H332: Harmful if inhaled is required according to the regulation 1272/2008/EC (corr. to Acute tox 2 / H 330: Fatal if inhaled for C(M)IT/MIT 3:1).
The major metabolite of C(M)IT/MIT, NMMA, did not produce clinical toxicological signs in a 14-day rat study up to 2500 mg/kg bw, giving a LD50 of 3550 mg/kg bw in males and 4100 mg/kg bw in females. Clinical toxicological signs (decreased respiration, piloerection, ataxia and CNS depression) were observed at 5000 mg/kg bw and congestion, hemorrhagic type responses and gastro-intestinal irritation were observed in dead from the 2500 mg/kg dose group.
Justification for classification or non-classification
Classification is justified on the basis of results obtained in well conducted, guideline compliant, oral, dermal or inhalation acute toxicity studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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