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Diss Factsheets
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EC number: 234-398-4 | CAS number: 11140-04-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Dosing concentration unclear.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- yes
- Remarks:
- lack of details on test substance, only limited examination parameters.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 73398-61-5
- Cas Number:
- 73398-61-5
- IUPAC Name:
- 73398-61-5
- Details on test material:
- - Name of test material (as cited in study report): only trade name given
- Physical state: yellowish, odourless liquid
- Analytical purity: no data
- Other: not water soluble
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 120 - 150 g
- Housing: 2 animals
- Diet: standard pellet diet (ssniff R, Intermast GmbH, Germany), ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily, 7 days/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10000 and 50000 ppm
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
approx. 1000 and 5000 mg/kg bw/day
Basis:
other: assuming a mean body weight of 200 g and a mean food intake of 20 g/day over the study period
- No. of animals per sex per dose:
- 20
- Control animals:
- yes, plain diet
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes, daily
BODY WEIGHT: Yes
- Time schedule for examinations: every 14 days
FOOD CONSUMPTION: Yes
URINALYSIS: Yes
- Time schedule for collection of urine: at the middle and end of study period
- Metabolism cages used for collection of urine: No data
- Animals fasted: No data
- Parameters checked:
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: at the middle and end of study period
- Animals fasted: No data
- How many animals: all animals
- Parameters checked: GOT, GPT, determination of free fatty acids and fatty acid esters
ORGAN WEIGHTS: Yes - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: No
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- CLINICAL SIGNS AND MORTALITY
No signs of systemic toxicity and no deaths occured.
BODY WEIGHT AND WEIGHT GAIN
No significant differences in the body weight gain of treated and control animals occured.
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study)
Food consumption increased from 15 - 17 g/ day to 20 - 22 g/ day during the study period and did not differ significantly from the untreated control group.
HAEMATOLOGY
Hemoglobin, Erythrocyte and Leukocyte parameters did not differ significantly from the control group.
CLINICAL CHEMISTRY
GOT and GPT values did not differ significantly from the control group.
Blood contents on free fatty acids and fatty acid esters did not differ significantly from the control group, indicating that the treatment did not influence the lipid metabolism.
URINALYSIS
The urine did not contain protein, glucose or urobilinogen. pH and urine sediment analysis were not changed.
ORGAN WEIGHTS
No significant differences between treated and control groups observed.
GROSS PATHOLOGY
No abnormalities observed.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 5 000 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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