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EC number: 608-554-0 | CAS number: 3090-56-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was not irritating to the skin.
The test substance caused irreversible damage to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- in vivo study already available
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No dates were provided.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Please refer to "Principles of method"
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Specific details on test material used for the study:
- No specific details for test material were provided.
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- No details provided.
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- Back: no amount spezified
Ear: 2 mL were applied - Duration of treatment / exposure:
- Back: 1, 5 and 15 min and 20 h
Ear: 20 h - Observation period:
- 8 days
- Number of animals:
- 2 animals were used for 1, 5, and 15 min exposure.
Another 2 animals were used for 20 h exposure. - Details on study design:
- TEST SITE
- Area of exposure: 2.5 X 2.5 on the back, outside of the ear
REMOVAL OF TEST SUBSTANCE
- Washing: with water
- Time after start of exposure: directly after exposure time was done. - Irritation parameter:
- edema score
- Remarks:
- 1, 5, 15 min and 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: back
- Irritation parameter:
- edema score
- Remarks:
- 1, 5, 15 min and 20 h exposure
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: back
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- probability of weak irritation
- Remarks:
- Application side: back
- Irritation parameter:
- erythema score
- Remarks:
- 1, 5, 15 min exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: back
- Irritation parameter:
- erythema score
- Remarks:
- 1, 5, 15 min and 20 h exposure
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: back
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: ear
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: ear
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: ear
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Time point:
- other: 8 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- Application side: ear
- Irritant / corrosive response data:
- After the application of the test substance for 1, 5 and 15 min to the back no effects were detected after 24 h and 8 days.
After the application of the test substance for 20 h to the back a slight redness was detected after 24 h but was not present after 8 days.
The application of the test substance to the ear for 20 h caused no detectable effects. - Other effects:
- No other local or systemic effects were observed.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo study already available
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967-09-26 to 1967-10-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Please refer to "Principles of method"
- Principles of method if other than guideline:
- No guideline was available while the study was conducted. Therefore BASF-internal standard was used.
- GLP compliance:
- no
- Specific details on test material used for the study:
- No specific details for test material were provided.
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- No details were provided.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- 0.05 mL
- Duration of treatment / exposure:
- Eyes were not rinsed.
- Observation period (in vivo):
- 9 days
- Number of animals or in vitro replicates:
- 2 animals
- Details on study design:
- SCORING SYSTEM:
Company internal grading was used during study performance. After guidelines were implemented this internal scoring was translated into the Draize scheme. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- probability of moderate irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Other effects:
- - Lesions and clinical observations: Secretion was obsereved for up to 48 h. Both animals developed remaining scar tissue on the eye lid of the treated eye after 72 h. After 72 h blood was detected in the eye of animal 2.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
A study was conducted similar to the OECD 404 guideline. The undiluted test substance was occlusively applied to the back of rabbits for 1, 5 and 15 min and 20 h. In addition it was applied to the ear for 20 h. Irritation parameters were recorded after 24 h and 8 days after administration. After 20 h exposure a slight redness was observed on the back of the animals that was reversible within 8 days. No effects were detected after any other exposure time or observation period. The test substance was concluded to be not skin irritating.
Eye irritation
A non-guideline study was conducted to determine the eye irritation potential of the test substance in rabbits. The undiluted test substance was applied to the right eye of 2 rabbits. The left eye was treated with saline solution as control. Observations were recorded after 1, 2, 3, 24, 48 and 72 h and on days 6 and 8 after treatment. Mean scores at 24/48/72 h were determined to be 2.0 for cornea opacity, 1.7 for conjunctivae and 0.17 for chemosis. Cornea opacity was not fully reversible within the observation time of 8 days after treatment. Therefore the test substance was concluded to cause irreversible effects to the eye.
Justification for classification or non-classification
Skin Irritation
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008, as amended for the eighth time in Regulation (EU) No 2016/218. As a result the substance is considered to be not classified for skin irritation.
Eye irritation
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008, as amended for the eighth time in Regulation (EU) No 2016/218. As a result the substance is considered to be classified for irreversible eye damage in Category 1 (H318: Causes serious eye damage).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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