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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967-09-25 to 1967-10-03
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
Please refer to "Principles of method"
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethanol, 2-(ethenylthio)-
EC Number:
608-554-0
Cas Number:
3090-56-0
Molecular formula:
C4H8OS
IUPAC Name:
Ethanol, 2-(ethenylthio)-
Test material form:
liquid
Specific details on test material used for the study:
No specific details for test material were provided.

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
No details were provided.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Remark on MMAD/GSD:
No details were provided.
Details on inhalation exposure:
200 L air/ h were run through a 5 cm thick layer of the test substance. The atmosphere temperature was 20 °C. The atmosphere was saturated with vapour.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
1.14 mg/L = 263 ppm (calculated from the amount of test substance weight loss during exposure)
No. of animals per sex per dose:
2 runs with each 6 animals, no details on sex distribution were provided.
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: No details on observation intervals provided. Animals were weighted before treatment and before sacrifice.
- Necropsy of survivors performed: yes
Statistics:
No statistical analysis was performed.

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
LC0
Effect level:
1.14 mg/L air (nominal)
Based on:
test mat. (dissolved fraction)
Exp. duration:
8 h
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1.14 mg/L air (nominal)
Based on:
test mat. (dissolved fraction)
Exp. duration:
8 h
Mortality:
No mortatity was observed.
Clinical signs:
other: No clinical signs were detected.
Body weight:
Mean body weight before treatment was 1225 g (1. group) and 1180 g (2. group).
Mean body weight after 7 days of observation was 1250 g (1. group) and 1300 g (2. group).
Gross pathology:
No changes were detected.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met