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EC number: 211-438-9 | CAS number: 645-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-07-14 to 2017-08-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- TOXI-COOP ZRT., 8230 Balatonfüred, Arácsi út 97., Hungary
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- >= 256 - <= 268 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- >= 270 °C
- Conclusions:
- The melting point of the test item was determined using DSC. The test item dehydrated at 178 °C. The melting point was in the range of 256 - 268 °C.
- Executive summary:
A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point/range of the test item using differential scanning calorimetry. The test item was weighed into an aluminium crucible under an inert atmosphere (nitrogen). Three tests with about 3 – 5 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a white powder at ambient conditions. The crucible was heated from room temperature to 500 °C with 10 °C/min heating rate. The test item dehydrated at 178 °C. The melting range of the test item was determined to be 256 to 268 °C at atmospheric pressure (1013 hPa).
Reference
Before the test the appearance of L-histidine monohydrochloride monohydrate was white crystals. After the experiments the test item was melted, blackened and its volume increased.
Dehydration of the test item was observed at a temperature of 178 - 180 °C. Using a linear heating rate of 10 °C/min the melting point of L-histidine monohydrochloride monohydrate was determined to be in the range of 256 - 268 °C (529 - 541 K). Based on the thermograms and the appearance of test item after the tests it was concluded that it started to decompose after melting.
Description of key information
The melting point of the test item was determined using DSC. The melting point was in the range of 256 - 268 °C.
Key value for chemical safety assessment
Additional information
A study was conducted according to OECD TG 102, Regulation (EC) No 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point/range of the test item using differential scanning calorimetry (reference 4.2-1). The test item was weighed into an aluminium crucible under an inert atmosphere (nitrogen). Three tests with about 3 – 5 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. The substance is a white powder at ambient conditions. The crucible was heated from room temperature to 500 °C with 10 °C/min heating rate. The melting range of the test item was determined to be 256 to 268 °C at atmospheric pressure (1013 hPa).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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