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EC number: 812-925-4 | CAS number: 1639345-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 12, 2016 - March 22, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- adopted 17. July 1992 “Fish, Acute Toxicity Test“
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- EC Number:
- 812-925-4
- Cas Number:
- 1639345-42-8
- Molecular formula:
- C6H12FNSi
- IUPAC Name:
- 4-[fluoro(dimethyl)silyl]butanenitrile
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
The water-accommodated fractions were prepared for the test. This was done by weighing the nominal loads, adding the corresponding amount of dilution water and shaking vigorously
for 24 hours in the first experiment respectively 23 hours in the second experiment. experiment.
The resulting solutions were filtrated through 0.45 μm Cellulose ester filters.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Strain: Danio rerio HAMILTON-BUCHANAN
- Source: Dehner Garten Center, 67433 Neustadt
- Age at study initiation (mean and range, SD): sexually immature young fish
- Length at study initiation (length definition, mean, range and SD): 2 +/- 1 cm
ACCLIMATION
- Acclimation period: at least 12 days
- Type and amount of food during acclimation: three times a day with warmwater fishfood , totalling about 1-2% of body weight per day
Husbandry
-Vessels: polyethylene aquaria
-Medium: chlorine-free tap water
-Photo period: 12/12 hours, using neon tubes
-Temperature: 23 +/- 2 °C
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 0.83 mmol/L
- Test temperature:
- experiment 1: 20.5 – 21.8 °C
experiment 2: 20.4– 21.2 °C - pH:
- experiment 1: 6.7 - 7.7
experiment 2: 6.5 -7.8 - Dissolved oxygen:
- The concentration of dissolved oxygen was at least 8.5 mg/L or 98 % in the first experiment respectively 7.7 mg/L or 85 % in the second experiment throughout the test.
- Salinity:
- not applicable
- Conductivity:
- 228 µS/cm at 25°C
- Nominal and measured concentrations:
- The measured concentrations were in a range of 98 % - 104 % of the nominal concentration in the 1st experiment
and between 82 % - 104 % of the nominal concentration in the 2nd experiment. Therefore, the determination of the results of was based on the nominal concentrations. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass aquaria, maximal volume 10 L
- Aeration: Yes
- Renewal rate of test solution (frequency/flow rate): static test
- No. of organisms per vessel: 7
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Good quality drinking water is used. The composition is analysed yearly by the supplier.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 12/12 hours using neon tubes
EFFECT PARAMETERS MEASURED: Mortality. After 24, 48, 72 and 96 h.
TEST CONCENTRATIONS
Experiment 1: 100 mg/L
Experiment 2: 10, 18, 32, 56, 100 mg/L
- Range finding study: no - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 94 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- but exposure is to hydrolysis products
- Basis for effect:
- mortality (fish)
- Details on results:
- Mortality of control:
Experiment 1: 1 out of seven
Experiment 2: 0 out of seven- Reported statistics and error estimates:
- 95% confidence interval was not determined due to mathematical reasons or inappropriate data.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Two experiments were performed.
The 1st experiment was performed as a limit test at the concentration 100 mg/L. Because significant mortality (57%) was observed in the treatment, a second experiment was performed using concentrations in the range of 10 – 100 mg/L.
In the 2nd experiment, only the highest concentrated treatment containing 100 mg/L showed 71% mortality.
A 96-hour LC50 value of 94 mg/L has been determined for the effects of the test substance on mortality of Danio rerio based on nominal exposure concentrations of the substance. The test substance hydrolyses in water and it is therefore likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
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