Registration Dossier
Registration Dossier
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EC number: 253-930-6 | CAS number: 38436-16-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- only a summary report was available to review
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- [2-(perfluorobutyl)ethyl]dichloro(methyl) silane
- IUPAC Name:
- [2-(perfluorobutyl)ethyl]dichloro(methyl) silane
- Reference substance name:
- Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- EC Number:
- 253-930-6
- EC Name:
- Dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- Cas Number:
- 38436-16-7
- Molecular formula:
- C7H7Cl2F9Si
- IUPAC Name:
- Dichloro(methyl)(3,3,4,4,5,5,6,6,6-nonafluorohexyl)silane
- Details on test material:
- [2-(perfluorobutyl)ethyl]dichloro(methyl)silane
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Langshaw Farms, Augusta, Michigan
- Age at study initiation: no information
- Weight at study initiation: no information
- Housing: Stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): no information
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS; no information
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: Shaved (abdomen); abraded and unabraded.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml to ear, 0.5 ml to intact abdomen and 0.5 ml to abraded abdomen - Duration of treatment / exposure:
- 1 day
- Number of animals:
- Three
Results and discussion
In vivo
Results
- Irritation parameter:
- other: necrosis
- Time point:
- other: 1 day
- Score:
- >= 3 - <= 5
- Reversibility:
- no data
- Remarks on result:
- other: Superficial to deep necrosis was observed on day one, so the dosing was discontinued and all animals were sacrificed.
- Irritant / corrosive response data:
- 24 hour contact with the test substance resulted in slight to moderate hyperemia, slight to moderate edema and superficial to deep necrosis.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- [2-(perfluorobutyl)ethyl]dichloro(methyl) silane has been tested for skin irritation in rabbits on abraded and unabraded skin, in a study conducted according to a protocol similar to OECD 404 and in compliance with the skin. It is concluded by the study authors that the test substance is severely irritating to the skin, probably equivalent to Category 1 (corrosive).
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