Registration Dossier
Registration Dossier
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EC number: 218-427-8 | CAS number: 2150-46-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis to methyl gentisate
- Author:
- Serra-Baldrich, E.; Rincon, C.; Guedes, A.; Tribo, M.J.; Barco, D. and A. Alomar
- Year:
- 2 009
- Bibliographic source:
- Contact Dermatitis 2009: 60: 225–226
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl 2,5-dihydroxybenzoate
- EC Number:
- 218-427-8
- EC Name:
- Methyl 2,5-dihydroxybenzoate
- Cas Number:
- 2150-46-1
- Molecular formula:
- C8H8O4
- IUPAC Name:
- methyl 2,5-dihydroxybenzoate
Constituent 1
Method
- Type of population:
- other: two adult females with melasma
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed:
- Sex: female
- Age: 44 - 47
- Race: not specified
- Other: Both suffered from melasma - Route of administration:
- dermal
- Details on study design:
- Patch testing to identify the allergenic ingredient in skin-lightening face masks.
Both patients had developed contact dermatitis to a skin-lightening face mask. This study reports on the results of the patch tests to identify the allergenic component.
The authors used the TRUE Test-baseline series and cosmetic series by Trolab fixed on the intact skin of the back with Hypafix (BSN Medical, Hamburg, Germany) acrylic adhesive tape. Readings were taken on Day 2 and again on Day 4, according to International Contact Dermatitis Research Group (ICDRG) criteria.
Methyl gentisate was applied at 0.05% in petrolatum.
Results and discussion
- Results of examinations:
- Methyl gentisate was identified as the allergenic component in the skin-bleaching fask mask that caused allergic contact dermatitis in two adult women.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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