Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 420-150-4 | CAS number: 80498-15-3 SP 807
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 25, 1996 to April 15, 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- Certificate included in report
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg dry material/L
- Sampling method: Duplicate samples from the control and the test solutions of SP807 were taken at the beginning and at the end of the test. Samples of ca. 5 mL were taken in polyethylene bottles.
- Sample storage conditions before analysis: frozen - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia
- Strain: Daphnia magna
- Source: TNO
- Age at study initiation (mean and range, SD): <24h
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- Ca. 205 mg CaCO3/L
- pH:
- 7.5-8.0
- Dissolved oxygen:
- 6.9-9.2 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg TOS/L
measured: 74 mg TOS/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 150 mL glass beaker
- Material, size, fill volume: glass, 150 mL, 100 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic media (DSWL) prepared from ground water
- Total organic carbon: 1.7 mg/L
- Chlorine: 2.72 mg/L
OTHER TEST CONDITIONS
- Photoperiod: 16h light, 8h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mobility and immobility, condition of mobile animals (svimming behaviour, colour or any other visually observable morphological or behavioural criterion). Observations were made after 24h and at the end of the test (48h). - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- >= 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- >= 74 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: dry matter
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 74 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: dry matter
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 2.68 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: active enzyme protein (aep)
- Basis for effect:
- mobility
- Conclusions:
- No immobilisation was observed following the exposure of Daphnia magna to the test substance at a concentration of 74 mg dry material/L. Due to the low toxicity of the test material, the 48-hour EC50 value of the substance was unable to be calculated. Therefore the following values were assumed:
The 48-hour EC50 value for the test substance with Daphnia magna was determined to be >74 mg dry material/L corresponding to 2.68 > mg active enzyme protein (aep)/L.
The no-observed effect concentration (NOEC) was 74 mg dry material/L corresponding to 2.68 mg aep/L. - Executive summary:
The acute toxicity of the test substance to Daphnia magna was assessed under static exposure conditions.The study was conducted according to OECD and EC guidelines, and in compliance with GLP.
A group of 20 Daphnia were exposed to the test substance for 48 hours at a nominal concentration of 100 mg dry material/L. Mean measured concentration was 74 mg dry material/L.
Verification of test concentrations was performed based on enzyme activity. The amount of measured enzyme (LACU/g) was then converted to mg dry matter/L in order to calculate the achieved measured concentrations. Measured concentrations ranged were 67 % of nominal at 0 hours and between 79 -84% at 48 hours. The average percentage present during the test was 74%
The numbers of immobilised daphnids were recorded for each test and control group after 24 and 48 hours. All results are expressed in terms of mean measured concentration.
No immobilisation in either the control or the test group was noted throughout the exposure period, and therefore the following values were estimated:
48-hour EC50: >100 mg dry matter/L corresponding to > 2.68 mg active enzyme protein (aep)/L
NOEC: 100 mg dry matter/L corresponding to 2.68 mg aep/L
Reference
Description of key information
No immobilisation was observed following the exposure of Daphnia magna to the test substance at a concentration of 74 mg dry material/L. Due to the low toxicity of the test material, the 48-hour EC50 value of the substance was unable to be calculated. Therefore the following values were assumed: The 48-hour EC50 value for the test substance with Daphnia magna was determined to be >74 mg dry material/L corresponding to 2.68 > mg aep/L. The no-observed effect concentration (NOEC) was 74 mg dry material/L corresponding to 2.68 mg aep/L.
Key value for chemical safety assessment
Additional information
The acute toxicity of the test substance to Daphnia magna was assessed under static exposure conditions.The study was conducted according to OECD and EC guidelines, and in compliance with GLP.
A group of 20 Daphnia were exposed to the test substance for 48 hours at a nominal concentration of 100 mg dry material/l. Mean measured concentration was 74 mg dry material/L.
Verification of test concentrations was performed based on enzyme activity. The amount of measured enzyme (LACU/g) was then converted to mg dry matter/L in order to calculate the achieved measured concentrations. Measured concentrations ranged were 67 % of nominal at 0 hours and between 79 -84% at 48 hours. The average percentage present during the test was 74%
The numbers of immobilised daphnids were recorded for each test and control group after 24 and 48 hours. All results are expressed in terms of mean measured concentration.
No immobilisation in either the control or the test group was noted throughout the exposure period, and therefore the following values were estimated:
48-hour EC50: >100 mg dry matter/L corresponding to > 2.68 mg aep/L
NOEC: 100 mg dry matter/L corresponding to 2.68 mg aep/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.