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EC number: 212-220-6 | CAS number: 770-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1997-05-19 to 1997-06-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl phosphorodichloridate
- EC Number:
- 212-220-6
- EC Name:
- Phenyl phosphorodichloridate
- Cas Number:
- 770-12-7
- Molecular formula:
- C6H5Cl2O2P
- IUPAC Name:
- phenyl dichlorophosphate
- Test material form:
- liquid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): from the aeration stage of the Severn Trent Water pic sewage treatment plant at Belper, Derbyshire, treating predominantly domestic sewage.
- loading rate: 30 mg suspended solid (ss/L) - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 58.5 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- COD
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- Standard culture medium:
Solution a
- KH2PO4 8.50 g/l
- K2HPO4 21.75 g/L
- Na2HPO4.2H2O 33.40 mg/L
- NH4Cl 0.50 g/L
- pH = 7.4
Solution b
- CaCL2 27.50 g/L
Solution c
- MgSO4.7H2O 22.50 g/L
Solution d
- FeCL3.6H2O 0.25 g/L
To 1 litre (Final volume) of purified water* is added the following volumes of solutions a to d
- 10 mL of solution a
- 1 mL of solution b
- 1 mL of solution c
- 1 mL of solutoin d
* Ion exchange and reverse osmosis treated tap water
Test concentrations
a) Inoculated culture medium in duplicate
b) 17.1 mg/L sodium benzoate with inoculum, equivalent to 10 mg carbon/L in duplicate
c) 58.5 mg/L test material with inocumum, equivalent to 20 mg carbon/L in duplicate
d) Toxicity control 58.5 mg/L test material plus 17.1 mg/L sodium benzoate with inoculum equivalent to 30 mg carbon/L, one vessel only.
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 52
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 58
- Sampling time:
- 29 d
Any other information on results incl. tables
Table 1: Inorganic carbon value on each sampling occasion
day
|
Control (mg IC) |
Sodium Benzoate (mg IC) |
ITC 716 (mg IC) |
ITC 716 plus sodium benzoate toxicity control (mg IC) |
||||||||||
R1 |
R2 |
R1 |
R2 |
R1 |
R2 |
|
||||||||
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
Abs 1 |
Abs 2 |
|
0 |
1.23 |
1.52 |
1.05 |
1.17 |
1.05 |
1.40 |
1.40 |
1.28 |
0.82 |
1.05 |
1.05 |
1.40 |
1.40 |
1.75 |
1 |
1.63 |
- |
3.83 |
- |
5.68 |
- |
3.59 |
- |
6.26 |
- |
3.94 |
- |
5.22 |
- |
2 |
7.96 |
- |
6.11 |
- |
14.42 |
- |
14.30 |
- |
6.34 |
- |
6.23 |
- |
16.84 |
- |
3 |
7.91 |
- |
7.80 |
- |
20.18 |
- |
29.81 |
- |
13.19 |
- |
20.07 |
- |
41.05 |
- |
6 |
15.05 |
- |
14.25 |
- |
27.02 |
- |
38.53 |
- |
29.07 |
- |
31.92 |
- |
55.40 |
- |
8 |
19.49 |
- |
18.93 |
- |
42.84 |
- |
41.14 |
- |
32.41 |
- |
37.29 |
- |
70.95 |
- |
10 |
21.07 |
- |
20.39 |
- |
43.38 |
- |
46.19 |
- |
32.56 |
- |
42.48 |
- |
76.28 |
- |
14 |
20.82 |
- |
22.04 |
- |
42.53 |
- |
49.21 |
- |
36.74 |
- |
44.09 |
- |
82.05 |
- |
16 |
21.58 |
- |
22.80 |
- |
46.04 |
- |
50.46 |
- |
39.51 |
- |
50.69 |
- |
89.64 |
- |
20 |
23.40 |
- |
23.51 |
- |
49.86 |
- |
50.95 |
- |
42.75 |
- |
52.26 |
- |
98.40 |
- |
22 |
27.06 |
- |
24.02 |
- |
52.16 |
- |
53.57 |
- |
50.10 |
- |
54.66 |
- |
99.97 |
- |
24 |
29.27 |
- |
27.11 |
- |
56.70 |
- |
58.21 |
- |
58.21 |
- |
58.32 |
- |
105.08 |
- |
27 |
33.49 |
- |
31.13 |
- |
60.43 |
- |
63.33 |
- |
63.54 |
- |
60.86 |
- |
112.06 |
- |
28 |
33.71 |
- |
34.24 |
- |
64.11 |
- |
63.47 |
- |
65.60 |
- |
64.96 |
- |
117.33 |
- |
29 |
33.49 |
0.70 |
34.34 |
0.46 |
64.77 |
0.70 |
62.86 |
0.58 |
70.91 |
0.35 |
66.78 |
0.35 |
123.81 |
0.46 |
R1 – R2 = replicates 1 & 2 Abs = Co2 absorber vessels - = value not determined
Percentage biodegradation value
Day |
% degradation Sodium Benzoate |
%degrdation phenyl dichlorophospahte |
% degradation phenyl deichlorophosphate + sodium benzoate (toxicity control) |
0 |
0 |
0 |
0 |
1 |
6 |
4 |
3 |
2 |
24 |
0 |
11 |
3 |
57 |
15 |
37 |
6 |
60 |
26 |
45 |
8 |
76 |
26 |
57 |
10 |
80 |
28 |
62 |
14 |
81 |
32 |
67 |
16 |
87 |
38 |
75 |
20 |
90 |
40 |
83 |
22 |
91 |
45 |
83 |
24 |
98 |
50 |
85 |
27 |
99 |
50 |
89 |
28 |
99 |
52 |
93 |
29* |
100 |
58 |
100 |
* Day 29 values corrected to include any carry-over of CO2detected in absorber 2
Total organic carbon (TOC) values in the culture vessels on day 0 and 28
test vessel |
TOC * Concentration in culture vessel |
||||
Day 0 |
Day 28 |
||||
mg C/L |
% nominal carbon content |
mg C/L |
% of initial carbon concentration |
% degradation |
|
Sodium Benzoate 10 mg C/L R1 |
11.80 |
118 |
1.81 |
15 |
85 |
Sodium Benzoate 10 mg C/L R2 |
11.98 |
120 |
1.79 |
15 |
85 |
Phenyl Dichlorophosphate 20 mg C/L R1 |
17.95 |
90 |
9.42 |
52 |
48 |
Phenyl Dichlorophosphate 20 mg C/L R2 |
20.16 |
101 |
11.55 |
57 |
43 |
Phenyl dichlorophosphate + sodium benzoate (toxicity control) 30 mg C/L |
30.38 |
101 |
2.66 |
9 |
91 |
* Corrected for control values R1 & R2 = replicates 1 and 2
Applicant's summary and conclusion
- Validity criteria fulfilled:
- no
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The percentage of degradation of phenyl dichlorophosphine is 52% after 28 days. The substance was not considered to be readily biodegradable
- Executive summary:
Biodegradation of Phenyldichlorophosphate has been determined according to OECD test guideline 301B. The biodegradation of Phenyldichlorophosphate was determined to be equal 52% after 28 days. The substance cannot be considered to be readily biodegradable.
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