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EC number: 926-195-0 | CAS number: 1176284-65-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 August 2015 to 20 August 2015
- Reliability:
- 1 (reliable without restriction)
- Reason / purpose for cross-reference:
- other: Basis for representation of test solution concentrations.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test substance is listed as ZWA 5496/100. The test substance, a brown liquid, is the reaction product of maleic anhydride, disproportioned tall oil fatty acid, linseed oil and methanol. The test substance was obtained from Allnex Belgium and was stored at room temperature (20 ± 5°C) and kept away from light.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- The test substance is listed as ZWA 5496/100. The test substance is the reaction product of maleic anhydride, disproportioned tall oil fatty acid, linseed oil and methanol. The test substance was obtained from Allnex Belgium and was stored at room temperature (20 ± 5°C).
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test species, Daphnia magna STRAUS, were from the in-house laboratory breeding culture since 27 September 2007. Young female daphnids selected for the test were an age of <24 h.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- The hardness of the deionised dilution water was 2.502 mmol/L or 250 mg CaCO3/L.
- Test temperature:
- The temperature of the test medium was 19.4°C to 20.7 °C and complied with the requirements of the protocol (18-22°C, constant within 2°C).
- pH:
- The pH during the test measured between 7.1 and 7.7 and complied with the requirements of the protocol (6.0-8.5, not varying by more than 1.5 unit).
- Dissolved oxygen:
- The oxygen concentrations measured during the test were between 8.5 and 8.7 mg/L and complied with the requirements of the protocol (≥3 mg/L at the end of the test).
- Salinity:
- No information provided.
- Conductivity:
- No information provided.
- Nominal and measured concentrations:
- The experimental test was performed with one nominal test substance concentration of 100 mg/L; the test solution was prepared using the water-accommodated fraction. The decision to test one nominal concentration was based on the results of the algae study (Muckle, 2015). Analytical monitoring was conducted on the basis of dissolved organic carbon (DOC). Due to a technical failure, the DOC was not determined in the treatment group at the end of the test. The failure was described as "uncritical" because, during a comparable study with algae, the measured DOC and in agreement at the same nominal concentration was in a similar range and stable under test conditions. In the algae study, the presence of the dissolved test item was only confirmed in the higher concentration treatment groups (32 - 100 mg/L); in the lower concentration treatment groups. The DOC in the test solutions was in the same range as the controls. Therefore, no calculation of the test item concentration based on the organic carbon contents of the test item and DOC measurement was performed. Therefore, in agreement with the evaluation of the algae study, the determination of results was based on the nominal concentrations, in agreement with OECD guidance document no. 23. OECD guidance document no. 23 states “For tests with chemicals that cannot be quantified by analytical methods at the concentrations causing effects, the effect concentration can be expressed based on the nominal concentrations”.
- Details on test conditions:
- One valid experiment was performed. The study was performed using one nominal test substance concentration containing 100 mg/L. For the test concentration, 20 Daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hour, the immobilised Daphnia were counted. None of the animals were immobilised in the control and in the treatment. Potassium dichromate K2Cr2O7 was used as a positive control in the reference study.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate K2Cr2O7 (CAS No. 7778-50-9) was used as a positive control in the reference study.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- One valid experiment was performed. The study was performed using one nominal concentration containing 100 mg/L. For the test concentration, 20 Daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hour, the immobilised Daphnia were counted. None of the animals were immobilised in the control and in the treatment. Potassium dichromate K2Cr2O7 was used as a positive control in the reference study.
- Results with reference substance (positive control):
- The 24 h EC50 was 1.6 mg/L within the required range of 0.6 mg/L and 1.7 mg/L. For the estimation of the EC50 of the positive control, the fit showed sufficient statistical correspondence of the data with the dose-response equation.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance did not induce acute immobilisation of Daphnia magna at a nominal concentration of 100 mg/L after 48 h of exposure. The 48 h NOEC was ≥ 100 mg/L based on one nominal concentration. The 48 h EC50 was ≥ 100 mg/L based on one nominal test substance concentration of 100 mg/L.
Reference
Description of key information
The key study was a static acute invertebrate toxicity test on the effects of the substance on the freshwater invertebrate Daphnia magna following OECD Guideline 202. No toxicity of the substance to the daphnids was observed; the 48-h NOEC was reported as ≥ 100 mg/L (based on the water-accommodated fraction); the 48-h LOEC and 48-h EC50 were each reported as > 100 mg/L (based on the water-accommodated fraction).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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