Registration Dossier
Registration Dossier
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EC number: 220-860-2 | CAS number: 2920-38-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- p-phenylbenzonitrile
- EC Number:
- 220-860-2
- EC Name:
- p-phenylbenzonitrile
- Cas Number:
- 2920-38-9
- Molecular formula:
- C13H9N
- IUPAC Name:
- [1,1'-biphenyl]-4-carbonitrile
- Reference substance name:
- p-phenylbenzaldehyde
- EC Number:
- 221-742-3
- EC Name:
- p-phenylbenzaldehyde
- Cas Number:
- 3218-36-8
- Molecular formula:
- C13H10O
- IUPAC Name:
- biphenyl-4-carbaldehyde
- Reference substance name:
- unknown
- IUPAC Name:
- unknown
- Test material form:
- solid: bulk
Constituent 1
impurity 1
impurity 2
- Specific details on test material used for the study:
- Batch FH III/TVT 281098
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 1h, 24 h, 48 h, 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 4-Phenylbenzonitrile has not to be classified as irritant based on GHS criteria.
- Executive summary:
4-Phenylbenzonitrile has not to be classified as irritant based on GHS criteria.
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