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EC number: 289-969-0 | CAS number: 90046-02-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Juniperus oxycedrus, Cupressaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 04 to 10, 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Considering the complex nature of the substance, the quantification of the substance in water was performed using a non specific method. The values obtained should be considered with caution for the purpose of CSA.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on 13 and 14 October 2014 / signed on 08 April 2015
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 80.8 - <= 232.2 mg/L
- Temp.:
- 20 °C
- pH:
- >= 4.58 - <= 4.83
- Remarks on result:
- other: solubility range for the tested nominal concentration range 303 – 1003 mg/L
- Conclusions:
- Considering a water solubility of the test item between 80.8 and 232.2 g/L at a loading rate of 303 - 1003 mg/L at 20.0 ± 0.5 °C (pH 4.58 - 5.26; 3 days of equilibrium), the substance is considered as slightly to moderately soluble in water.
- Executive summary:
The water solubility of the test item was determined under GLP according to OECD 105 Guideline and EU Method A.6 using the flask method.
The concentration of the test item dissolved in water was determined by measurement of DOC concentration (dissolved organic carbon) in the filtrated test solutions using TOC analyser.
Using a loading rate of 501mg/L, no significant difference between the concentrations of test item obtained at 20.5 ± 0.5 °C after 1, 2 or 3 days of equilibration was observed. Therefore, the equilibrium was considered as reached after 3 days at this loading rate.
Dependency of the solubility of the substance and the pH on the loading rate (nominal concentration) were perceived in the study. Therefore, no exact value for the solubility of the test item in water can be stated.
The solubility for the tested nominal concentration range 303-1003 mg/L was stated as a range between 80.8 and 232.2 mg/L at 20.0 ± 0.5 °C and pH 4.58 - 5.26 after 3 days of equilibrium. These values are estimated to correspond at about 24.6 % of the test item (mean value) dissolved in water relating to the nominal concentration of the test item.
Reference
All measurements on day 3 (flasks 1A-C and 2 - 6) were included in the calculation of the solubility of the test item in water.
Table 4.8/7: Measurements used for Calculation of Solubility
Flask |
Measured concentration of test item (mg/l) |
Nominal concentration of test item (mg/l) |
Dissolved Part [%] |
pH value |
2 |
36.2 |
103 |
35.1** |
5.26 |
3 |
80.8 |
303 |
26.7 |
4.83 |
1* |
124.9 |
501 |
24.9 |
*** |
4 |
147.5 |
601 |
24.5 |
4.74 |
5 |
190.5 |
804 |
23.7 |
4.59 |
6 |
232.2 |
1003 |
23.1 |
4.58 |
* mean value of flasks 1A-C
** value was stated as outlier (Grubbs outlier test)
*** was not measured using pH meter
As solubility was dependent on nominal concentration, no exact value for the solubility of the test item in water can be stated. The solubility range for the tested nominal concentration 303 – 1003 mg/L is 80.8 – 232.2 mg/L at 20.0 ± 0.5 °C (80.8 – 232.2 * 10-3 kg/m3 in SI units), corresponding to 24.6 % of the test item (mean value) relating to the nominal concentration of the test item.
DISCUSSION
The solubility of the test item in water was determined from the measured concentrations of DOC in the filtrated test solutions.
Equilibrium was considered as reached after 3 days.
Dependency of solubility on amount of the test item (nominal load) was perceived in the study. Therefore, no exact value for the solubility of the test item in water can be stated.
The solubility range for the tested nominal concentration 303 – 1003 mg/L is 80.8 –232.2 mg/L at 20.0 ± 0.5 °C, corresponding to 24.6 % of the test item (mean value) relating to the nominal concentration of the test item. The value for the nominal load 103 mg/L was stated as outlier.
Dependency of pH value on amount of the test item (nominal load) was perceived, too. The higher the nominal load of the test item, the lower is the pH value.
No observations arousing doubts concerning the accuracy of the results and the validity of the study were made.
Description of key information
The water solubility of the test item was measured between 80.8 and 232.2 g/L using a loading rate of 303 - 1003 mg/L at 20.0 ± 0.5 °C (pH 4.58 - 5.26; 3 days of equilibrium).
The substance is considered as slightly to moderately soluble in water pending on the lodaing rate.
Key value for chemical safety assessment
Additional information
A reliable experimental study, conducted according to a recognized OECD/EC method (flask method) and under GLP is available. Despite restrictions due to the complex nature of the substance and the non specific method used to quantify the substance in water, the study is considered as a key study but the values obtained should be considered with caution for the purpose of CSA.
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