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EC number: 236-112-3 | CAS number: 13170-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: Data waiving (study scientifically not necessary): The substance decomposes very fast in the main hydrolysis product acetic acid which has the harmonized classification of Skin Corr. 1B; H314: 10 % ≤ C < 90 % and thus the substance should be classified in the same category.
Eye irritation: Data waiving (study scientifically not necessary): In accordance with column 2 of REACH Annexes VII and VIII, the study does not need to be conducted since the substance is classified as corrosive to the skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The substance decomposes very fast in the main hydrolysis product acetic acid which has the harmonized classification of Skin Corr. 1B; H314: 10 % ≤ C < 90 % and thus the substance should be classified in the same category.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In accordance with column 2 of REACH Annexes VII and VIII, the study does not need to be conducted since the substance is classified as corrosive to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion: Data waiving (study scientifically not necessary): In accordance with column 2 of REACH Annexes VII and VIII, the study does not need to be conducted since the substance is classified as corrosive to the skin.
Eye irritation: Data waiving (study scientifically not necessary): In accordance with column 2 of REACH Annexes VII and VIII, the study does not need to be conducted since the substance is classified as corrosive to the skin.
Justification for classification or non-classification
The substance is classified as skin corrosive based on a weight of evidence approach:
- pH value: Endpoint record pH.04.20_01. In accordance with the method CIPAC 75.3 and GLP, the pH of diacetoxydi-tert-butoxysilane was measured to be 3.02 and therefore, the substance was determined to be strong acid.
- Worth and Cronin (2001) [1]: The aim of the study conducted by Worth and Cronin was to develop classification models based on pH data for predicting the potential of chemicals to cause skin corrosion, skin irritation and eye irritation based on compilation of data sets of 44 chemicals. According to the predicting model results, if pH <3.9 of if pH > 10.5, then the substance is predicted to be corrosive.
- Acetic acid (CAS No. 64 -19 -7): Diacetoxydi-tert-butoxysilane is an acetoxysilanes and have three acetoxy groups linked to a silicon atom. In contact with water and even in moisture, diacetoxydi-tert-butoxysilane hydrolyses into acetic acid and corresponding trisilanol (1 mole of the test item produces 2 moles of acetic acid). According to Regulation (EC) No. 1272/2008 [2], acetic acid is included in the List of harmonised classification and labelling of hazardous substances (Index No. 607-002-00-6) and it is classified as Skin Corr. 1A, H314 (Skin Corr. 1A; H314: C ≥ 90 %; Skin Corr. 1B; H314: 10 % ≤ C < 90 %).
Diacetoxydi-tert-butoxysilane polymerizes triggered by hydrolysis in contact with water and the degradation product acetic acid decreases the pH of the test solution. In fact the pH of the test item was determined to be 3.02 due to the hydrolysis product acetic acid. Taking into account that the substance is a strong acid (pH = 3.02) and the harmonised classification of the hydrolysis product acetic acid according to current regulations, diacetoxydi-tert-butoxysilane is determined to be corrosive to the skin.
Therefore, and based on the available information on diacetoxydi-tert-butoxysilane (pH = 3.02, acetic acid = Skin Corr. 1B; H314 when 10% < C < 90%), the substance is classified as Skin Corrosive, hazard category 1B.
References:
[1]: Worth, A.P and Cronin, M.T.D. 2001. The use of pH measurements to predict the potential of chemicals to cause acute dermal and ocular toxicity. Toxicology 169 (2001) 119 -131.
[2]: Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.