Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-404-7 | CAS number: 106-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report, which meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: internal company guideline similar to OECD 401
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- before GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-phenylenediamine
- EC Number:
- 203-404-7
- EC Name:
- p-phenylenediamine
- Cas Number:
- 106-50-3
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,4-diamine
- Details on test material:
- - Name of test material (as cited in study report): Nako H (p-Phenylenediamin)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- strain Hoe: WISKf (SPF71), weigth 160-180 g (median 170 g, s= 6,29), only females were used, because pretests didn't show sex-linked differences in sensitivity.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame oil
- Doses:
- concentration: 1 % solution (1g in 100ml Sesame oil)
Dose: 50 mg/kg bw (1% concentration)
Dose: 80 mg/kg bw (1% concentration)
Dose: 125 mg/kg bw (1% concentration)
Dose: 160 mg/kg bw (1% concentration)
Dose: 200 mg/kg bw (1% concentration) - No. of animals per sex per dose:
- 10 females per dose
- Control animals:
- no
- Details on study design:
- Food was withheld from 16 h prior to 2 h after substance administration. The duration of the observation period was 14 days after administration. Individual weights were determined weekly.
Food: ALTROMIN 1324 from Altromin GmbH in Lage/Lippe, tap water - supply was unrestricted available
Cage: plastic cages with wood shavings - Statistics:
- Probit analysis according to Linder and Weber, confidence interval according to Cavallis-Sforza
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 137 mg/kg bw
- Based on:
- test mat.
- Mortality:
- During the 14 day observation period lethality was as follows:
at 50 mg/kg bw. 0 of 10
at 80 mg/kg bw. 0 of 10
at 125 mg/kg bw. 3 of 10
at 160 mg/kg bw. 8 of 10
at 200 mg/kg bw.10 of 10 - Clinical signs:
- other: Intoxicated animals died between 24 minutes and 24 hours after application. Symptoms observed: squatting posture, prone position, lateral position, motor excitation, passivity, stupor, disequilibrium, coat bristling, panting, narrow palpebral fissure, my
- Gross pathology:
- Surviving animals sacrificed at the end of the observation period didn't showed any abnormalities.
Animals that died during observation period revealed: stomach filled with red/brown oily liquid, small intestine filled with white-grey slimy substance
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD 50: 137 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.