Registration Dossier
Registration Dossier
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EC number: 232-102-8 | CAS number: 7786-67-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In-vitro Gene mutation in bacteria (AMES acc. to OECD TG 471, GLP): negative (BASF2010; 40M0358/10M055).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Avaliable toxicity data for isopulegol have been derived with or have been filed under the identity of a respective enantiomer, i.e. (1R,2S,5R)-5-methyl-2-(1-methylethenyl)-cyclohexanol (CAS 89 -79 -2). This enantiomer represents one main component of the registered substance DL-isopulegol and the respective data allow to cover the given toxicological endpoint.
In-vitro:
Gene mutation in bacteria
In the key study according to OECD TG 471 and GLP, isopulegol was not mutagenic with and without metabolic activation when tested up to 5000 μg/plate using Salmonella typhimurium TA 1535, TA 100, TA 1537, TA 98 and E. coli WP2 uvrA (BASF2010; 40M0358/10M055).
Justification for classification or non-classification
The present data on genetic toxicity do not fulfill the criteria laid down in 67/548/EEC and regulation (EU) 1272/2008 and therefore, a non-classification is warranted.
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