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EC number: 276-292-0 | CAS number: 72017-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 January,1980 to 08 February, 1980.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- None
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- None
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Disodium[4-{[5-chloro-2-(hydroxy-O)-3-nitrophenyl]diazenyl-N1}-3-methyl-1-phenyl-1H-pyrazol-5-olato(2-)-O][3-{[1-(3-chlorophenyl)-5-(hydroxy-O)-3-methyl-1H-pyrazol-4-yl]diazenyl-N1}-4-(hydroxy-kO)-5-nitrobenzenesulfonato(3-)]chromate(2-)
- Cas Number:
- 72017-66-4
- Molecular formula:
- C32H19Na2Cl2CrN10O11S
- IUPAC Name:
- Disodium[4-{[5-chloro-2-(hydroxy-O)-3-nitrophenyl]diazenyl-N1}-3-methyl-1-phenyl-1H-pyrazol-5-olato(2-)-O][3-{[1-(3-chlorophenyl)-5-(hydroxy-O)-3-methyl-1H-pyrazol-4-yl]diazenyl-N1}-4-(hydroxy-kO)-5-nitrobenzenesulfonato(3-)]chromate(2-)
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Test Material: FAT 20202/B
Physical Appearance: Solid
Test Material received date: 02 Januaray 1980
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAIf (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 to 8 weeks old
- Housing: Macrolon cages (type 3)
- Diet: ad libitum rat food - NAFAG, Gossau SG
- Water: ad libitum water
- Acclimation period: a minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2 °C,
- Humidity: 55 ± 10 %
- Photoperiod (hrs dark / hrs light): 10 hours light cycle day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- Volume (ml/kg body-weight): 10 and 20
Vehicle: polyethylene glycol (PAG 400); Fluka AG, Buchs SG, Art. 81170 - Doses:
- 2000, 2500, 3000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations for mortality and clinical signs: daily
- Frequency of weighing: weekly (prior to dosing, day 7 and day 14)
- Necropsy of survivors performed: yes - Statistics:
- Probit method
Results and discussion
- Preliminary study:
- None
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 696 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 267 - <= 3 095
- Mortality:
- No mortality was seen at 2000 mg/kg bw, however, % mortality observed was 50 (5 females), 70 (2 males and 5 females) and 100 (5 males and 5 females) at 2500, 3000 and 5000 mg/kg bw, respectively.
- Clinical signs:
- other: edation, dyspnoea, exophthalmos, ruffled fur, diarrhoea and curved body position were the clinical signs observed. The surviving animals recovered by day 8.
- Gross pathology:
- No substance related gross organ changes were seen.
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dose (LD50) of compound FAT 20202/B in rats is 2696 mg/kg bw.
- Executive summary:
The acute oral toxicity of FAT 20202/B was evaluated using methodology similar to OECD Guideline 401. In this study, gropus of rats each containing 5 males and 5 females, were administered FAT 20202/B at 2000, 2500, 3000 and 5000 mg/kg bw via gavage. After administration of the compound, the animals were observed for 14 days. No mortality was seen at 2000 mg/kg bw, however % mortality observed was 50 (5 females), 70 (2 males and 5 females) and 100 (5 males and 5 females) at 2500, 3000 and 5000 mg/kg bw respectively. Sedation, dyspnoea, exophthalmos, ruffled fur, diarrhoea and curved body position were the clinical signs observed. The surviving animals recovered by day 8. At autopsy no changes caused by the administration of FAT 20202/B were seen.In conclusion, the acute oral LD50 of FAT 20202/B in rats of both sexes observed over a period of 14 days is 2696 mg/kg bw.
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