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Diss Factsheets
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EC number: 807-821-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6-26 February 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Data have been generated according to current internationally recognised study guidelines and in accordance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Details on study design: HPLC method:
- Stationary Phase (HPLC Column): ACE 5 CN 150 × 4.6 mm, HPLC Column, No.: A47728 Merck-Hitachi LaChrom HPLC system: D-7000 Interface, No.: 1126-175 L-7100 HPLC pump, No.: 1388-056L-7200 Autosampler, No.: 1380-033 L-7400 UV Detector, No.: 1374-025 L-7360 Column Oven, No: 00118060 L-7614 Degasser, No.: 144116A0094 Ultrasonic bath: Elmasonic S300H, ELMA, No.: 010890105 Balances: BP221S Sartorius, No.: 11809117, Sartorius L220P, No.: 38100037 pH meter: Mettler Toledo, SevenEasy S20, No.: 1231025119 Water purification system: MILLIPORE, DIRECT Q8 UV, F3SA78247A Spectrophotometer: Hitachi U-2910, No.: 2221-004HPLC Conditions: Detector: UV at 254 nm Mobil Phase: 10 mM NaH2PO4 buffer solution (pH=6.0)/Acetonitrile=8/2 Flow: 1 ml/min. Injection volume: 20 μl Temperature: 25 °CDetermination of the retention times: Three series of the above reference solutions and the test item solution were measured alternately, with two replicate injections. For the determination of t0 (t0 = retention time of the unretarded component) sodium nitrate solution was injected. The retention times were determined.
- Type:
- log Koc
- Value:
- <= 1.25
- Temp.:
- 25 °C
- Type:
- Koc
- Value:
- <= 17.78
- Temp.:
- 25 °C
- Validity criteria fulfilled:
- yes
- Conclusions:
- The log Koc is <1.25
- Executive summary:
The adsorption coefficient was measured by the HPLC method in accordance with the OECD 121 test guideline in compliance with GLP. The log Koc is <1.25.
Reference
Due to the fact that BK-659 eluted before t0, the log Koc and Koc of BK-659 is lower than log Koc and Koc of the first reference substance (Acetanilide)
Description of key information
The adsorption coefficient was measured by the HPLC method in accordance with the OECD 121 test guideline in compliance with GLP. The log Koc is <1.25.
Key value for chemical safety assessment
- Koc at 20 °C:
- 17.78
Additional information
[LogKoc: 1.25]
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