Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 229-319-5 | CAS number: 6471-78-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data are available for skin sensitisation of 5-methoxy-2-methylsulphanilic acid.
We can assume the absence of concern regarding skin sensitisation of 5-methoxy-2-methylsulphanilic acid based on read-across with two compounds of similar structure (more similar substance: 4-aminotoluene-3-sulfonic acid; less similar substance: sulphanilic acid).
For justification of read-across see attachment document in section 13.
From information published in ECHA website, compounds with similar structure to 5-methoxy-2-methylsulphanilic acid are of none concern for skin sensitisation: in ECHA website LLNA tests of 2010 regarding 4-aminotoluene-3-sulfonic acid and sulphanilic acid were reported and both the substances resulted not skin sensitizers. Despite of experimental data published on ECHA website (LLNA test), Sulphanic acid is classified H317 (Skin sens. cat. 1) according to Annex VI of CLP Regulation (EC n. 1272/2008). However, reasonably there is no concern regarding skin sensatisation for 5-methoxy-2-methylsulphanilic acid based on the experimental data (LLNA test) for more similar substance using for read-across (4-aminotoluene-3-sulfonic acid).
The public ECHA database contains data that are proprietary and cannot be used without the formal consent of the owner. In this summary, some of them have been used for precautionary purposes and for the benefit of the human health and the environment. Those data are not necessary for the registration of the target substance which is used exclusively as isolated and transported intermediate, but they can be very helpful for a better definition of the (eco) toxicological property of the substance. No other use and no commercial advantage will derive from the use of those data.
Migrated from Short description of key information:
5-methoxy-2-methylsulphanilic acid should be not sensitizing for skin based on data available for similar substances.
Justification for selection of skin sensitisation endpoint:
Read across with similar substances.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC n. 1272/2008) : "skin sensitiser means a substance that will lead to an allergic response following skin contact". 5-methoxy-2-methylsulphanilic acid should be not skin sensitizer based on data available regarding substances with similar structure (4-aminotoluene-3-sulfonic acid and sulphanilic acid).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
