Registration Dossier
Registration Dossier
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EC number: 268-667-2 | CAS number: 68133-24-4
Endpoint summary
Administrative data
Description of key information
The similar substance 1 was tested in a local lymphnode assay in 5 mice per dose (at 100, 50 and 25%). Following 3 days of treatment, on day 6 mice received 125I-iododeoxyuridine and 10-5M fluorodeoxyuridine and were terminated 5 hours later. The lymphnodes were excised, pooled and prepared cells suspensions were assessed for 125I incorporation. Simulation indices were calculated to be 2.72, 3.56 and 4.44 at 25, 50 and 100%. The EC3 was calculated to be 33.25%. Based on this finding the substance is considered a skin sensitizer (category 1B).
A prediction with the QSAR dyes RC 2.0 Developed by Milano Chemometrics and QASR research group Dept. Earth and Environmental Science, University Milano was performed on Reactive Blue 171, and the substance resulted not classified.
Read across is discussed in section 13
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The test substance needs to be classified as a skin sensitizer: category 1B H317 according to Regulation (EC) No 1272/2008 (CLP)
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