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EC number: 204-129-5 | CAS number: 116-16-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity of Some Perhalogenated Acetones
- Author:
- Joseph F. Borzelleca, David Lester
- Year:
- 1 965
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACOLOGY 7, 592-597 (1965)
Materials and methods
- Principles of method if other than guideline:
- Adult albino rats, averaging about 150 g in weight, were the test animals. They were exposed in groups of 10, 5 males and 5 females, for periods
of 0.5, 1, 3, or 6 hours. With each compound 50-120 rats were used in a series of exposures to concentrations of vapor which produced
mortalities bracketing the 50% level. Survivors were observed for 15 days following the exposure. The LC50 was estimated by inspection of
a log-log plot of concentration vs. percentage mortality. - GLP compliance:
- not specified
- Test type:
- other: 4 dose groups
- Limit test:
- no
Test material
- Reference substance name:
- Hexachloroacetone
- EC Number:
- 204-129-5
- EC Name:
- Hexachloroacetone
- Cas Number:
- 116-16-5
- Molecular formula:
- C3Cl6O
- IUPAC Name:
- hexachloropropan-2-one
- Details on test material:
- Boiling point: 204 °C
Specific gravity: 1.73 (25°C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Adult albino rats, averaging about 150 g in weight, were the test animals. They were exposed in groups of 10, 5 males and 5 females, for periods
of 0.5, 1, 3, or 6 hours. With each compound 50-120 rats were used in a series of exposures to concentrations of vapor which produced
mortalities bracketing the 50% level. Survivors were observed for 15 days following the exposure.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The vapor concentrations of the liquid acetones were prepared by the syringe method: the liquid was metered into the air stream by means of a
motor-driven syringe. The bottom of the mixing chamber was heated to ensure prompt vaporization of the liquids. The mixture was led into a
10-liter glass desiccator which served as the exposure chamber. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- > 0.5 - <= 6 h
- Remarks on duration:
- 4 dose groups
- Concentrations:
- no data
- No. of animals per sex per dose:
- groups of 10, 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- Adult albino rats, averaging about 150 g in weight, were the test animals. They were exposed in groups of 10, 5 males and 5 females, for periods
of 0.5, 1, 3, or 6 hours. With each compound 50-120 rats were used in a series of exposures to concentrations of vapor which produced
mortalities bracketing the 50% level. Survivors were observed for 15 days following the exposure.
The vapor concentrations of the liquid acetones were prepared by the syringe method: the liquid was metered into the air stream by means of a
motor-driven syringe. The bottom of the mixing chamber was heated to ensure prompt vaporization of the liquids. The mixture was led into a
10-liter glass desiccator which served as the exposure chamber. - Statistics:
- The LC50 was estimated by inspection of a log-log plot of concentration vs. percentage mortality.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 660 ppm
- Based on:
- test mat.
- Exp. duration:
- 3 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 360 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- Most of the fatalities occurred 2-6 days after exposure. No sex difference in response was evident.
The cause of death is not well defined. In the case of hexachloroacetone administered by inhalation the extent of the pulmonary damage and its long persistence suggest that this might be the cause of death. The pulmonary absorption is less than half the gastrointestinal absorption. These
calculations are interpreted as evidence that the lethal action of hexachloroacetone is not manifested entirely systemically. - Clinical signs:
- other: When the damage to the lung was slight and seen only microscopically) the lung weight was usually' within the normal range. When lung edema was evident upon gross examination, the lung weight was increased. Liver weights in all cases were within the norm
- Body weight:
- no data
- Gross pathology:
- All animals, both survivors and nonsurvivors, were autopsied, and the lungs, liver, heart, and kidneys were examined grossly and microscopically.
The lungs and livers of the rats which were sacrificed were weighed. There were no histopathologic findings in heart, kidney or liver.
When the damage to the lung was slight and seen only microscopically) the lung weight was usually' within the normal range. When lung edema
was evident upon gross examination, the lung weight was increased. Liver weights in all cases were within the normal range. Gross examination of
the lungs immediately after- death presented a picture of widespread hemorrhage. Edema, hemorrhage and congestion of the lungs was evident
microscopically 15 days after termination of exposures to hexachloroacetone, with little indication of repair of the injury.
Any other information on results incl. tables
No sex difference in response was evident. Most of the fatalities occurred 2-6 days after exposure.
Pulmonary edema is a prominent feature of the response to inhalation of hexachloroacetone.
When the damage to the lung was slight and seen only microscopically, the lung weight was usually within the normal range. When lung edema was evident upon gross examination, the lung weight was increased. Liver weights in all cases were within the normal range. Gross examination of the lungs immediately after- death presented a picture of widespread hemorrhage only in the case of hexachloroacetone. Edema, hemorrhage and congestion of the lungs were evident microscopically 15 days after termination of exposures to hexachloroacetone, with little indication of repair of the injury. There were no histopathology findings in heart, kidney or liver.Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- LC50 = 660 ppm (3h) and 360 ppm (6 h) bw (determined with 50-120, male/female).
- Executive summary:
The acute LD 50 of inhalative administration is presented. The compound was administrated by inhalation to rats. The compound caused some depression of the central nervous system, but, otherwise, no specific toxic signs were associated with lethal doses. Pulmonary edema is a prominent feature of the responsetoinhalation of hexachloroacetone, but only minor or negligible lung-irritant effects were observed from exposure to the other compounds.
The mechanism of the lethal action of the latter compounds is not apparent in these studies. In the case of hexachloroacetone administered by inhalation the extent of the pulmonary damage and its long persistence
suggest that this might be the cause of death. The pulmonary absorption is less than half the gastrointestinal absorption. These
calculations are interpreted as evidence that the lethal action of hexachloroacetone is not manifested entirely systemically.
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