Registration Dossier
Registration Dossier
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EC number: 237-041-0 | CAS number: 13596-23-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In accordance with Column 2 of REACH Annex VII, the in vitro bacterial mutagenicity study (required in Section 8.4.1) does not need to be conducted as the study is technically not feasible. The substance reacts vigorously in contact with water and with solvents recommended in the test guideline. A statement from the testing laboratory regarding the conduct of genetic toxicity experiments with the related decachlorotetrasilane is attached as supporting information. The registration substance behaves in an identical manner to that described.
Supporting information is available from the structurally-related substance trichlorosilane (CAS 10025-78-2) as follows: Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 or TA 1538 (similar to OECD TG 471) (Dow Corning Corporation, 1981).
Endpoint conclusion
- Endpoint conclusion:
- no study available
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Supporting information is available from the structurally similar substance, trichlorosilane, which was tested according to a protocol that is similar to OECD 471 and in compliance with GLP (Dow Corning Corporation, 1981). No test substance related increase in the number of reversions was observed when tested to limit concentration in Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 or TA 1538, with and without metabolic activation. Appropriate solvent and positive controls were included and gave expected results. The substance is considered to be non-mutagenic under the conditions of the test.
Read-across of supporting information from trichlorosilane for bacterial mutagenicity is considered to be appropriate as this and the registered substance are structurally similar as both have silicon atoms attached to two or more chlorine atoms. The Si-Cl bond in both substances is expected to hydrolyse rapidly to form hydrogen chloride and, ultimately, (poly)silicic acid.
Justification for classification or non-classification
Based on the available data for trichlorosilane, octachlorotrisilane does not require classification for mutagenicity according to Regulation (EC) No 1272/2008.
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