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Diss Factsheets
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EC number: 289-339-5 | CAS number: 87741-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- The physiological action of butadiene, butene-2 and isoprene
- Author:
- Larionov, L.F. et al.
- Year:
- 1 934
- Bibliographic source:
- Kazanskii Meditsinkii Zhurnal. 30; 440-445 (HSE translation no. 10855)
- Reference Type:
- publication
- Title:
- Studies on the inhalation of 1,3-butadiene
- Author:
- Carpenter, C.P. et al.
- Year:
- 1 944
- Bibliographic source:
- J Ind Hyg Toxicol 26; 69-78
- Reference Type:
- publication
- Title:
- Concerning derivation of highest single MAK of divinyl in air
- Author:
- Ripp, G.K.
- Year:
- 1 965
- Bibliographic source:
- Tr Omsk Med Inst. 69; 134-140 (in Russian, paper summarised in Ripp (1967))
- Reference Type:
- publication
- Title:
- Effect of divinyl on light sensitivity of the eyes
- Author:
- Ripp, G.K.
- Year:
- 1 965
- Bibliographic source:
- Tr Omsk Med Inst. 61; 189-197 (in Russian, paper summarised in Ripp (1967))
- Reference Type:
- publication
- Title:
- Sanitary validation of the maximum permissible concentration of divinyl in atmospheric air
- Author:
- Ripp, G.K.
- Year:
- 1 967
- Bibliographic source:
- In: VA Ryazanova (ed.). Biologicheskoe deystvie i gigienicheskoe znachenie atmosfernykh zagryazneniy. Moscow: Izdatel¿stvo Meditsina 33-54 (translation prepared for US Environmental Protection Agency PB-212 599)
Materials and methods
- Type of study / information:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
Inhalation exposure of human volunteers to 1,3-Butadiene. - Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
- CAS number: 106-99-0
- EINECS number: 203-450-8
Constituent 1
Method
- Details on study design:
- Inhalation exposure of human volunteers to 1,3-Butadiene.
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
There is little information available on the effects of single exposure and the data are of poor quality.
A slight increase in pulse rate was noted as a result of breathing 10,000 ppm butadiene for
5 minutes (Larionov et al., 1934). Blood pressure and respiration were apparently not markedly
affected. Two volunteers exposed to 8,000 ppm butadiene for 8 hours reported feeling alert and
'capable of meeting emergencies' (Carpenter et al., 1944). Unsteadiness was noted in
psychomotor response, measured by a tapping test, at 4,000 ppm but not at 8,000 ppm.
In separate studies with 4 volunteers per test, sensitivity of the eye to light was reported to be altered
following exposure to 1.7 ppm butadiene and an electrocortical conditioned response (lightstimulated
desynchronisation of a-rhythm of the brain) occurred at 1.6 ppm (Ripp, 1965a, b, 1967).
No effect levels were 1.6 ppm and 1.4 ppm, respectively. However these studies are unconventional
and unreliable and the results are considered of doubtful significance.
Applicant's summary and conclusion
- Executive summary:
The limited data available indicate that butadiene is of low acute toxicity in humans. A concentration of 8,000 ppm can be tolerated for several hours without adverse symptoms. The main acute effect of butadiene is irritancy. Butadiene is an irritant to the eyes, nose and mouth at high concentrations, of the order of thousands of ppm.
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