Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 201-800-4 | CAS number: 88-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
N-Vinyl-2 -pyrrolidone has not been specifically examined for toxicity to reproduction but is not expected to be a specific hazard in this regard based on negative pathological reproductive organ findings observed in a 2 -year inhalation cancer study (BASF, 1992)
and a key guideline Developmental/teratogenicity study (BASF, 2001).
The substance is classified as a Catergory 2 carcinogen and, therefore, exposures should be prevented / minimized to as low a reasonably achievable.Short description of key information:
N-Vinyl-2-pyrrolidone has not been specifically examined for toxicity to reproduction. The substance is classified as a Catergory 2 carcinogen. Exposures should be prevented / minimized to as low as reasonably achievable.
Effects on developmental toxicity
Description of key information
Not expected to be a developmental toxicant in the absence of maternal toxicity.
Additional information
In an OECD 414 Prenatal Development Toxicity study performed according to GLP guidelines (BASF AG, 2001), Wistar rats exposed daily by inhalation (whole body) for 6 hours per day for 20 days (exposure period from day 6 post coitum to day 19 pos coitum) to either 0, 1, 5 or 20 ppm, effects on fertility and fetal development were only present at doses that were clearly maternally toxic. The examinations revealed no difference in the sex distribution between treated and control groups. The placental weights were similar for all groups. In contrast, the mean body weight of the fetuses within the group treated with 20 ppm of test substance was significantly reduced below the control value and was considered to be substance-related. The fetuses showed neither external nor soft tissue malformations. Skeletal malformations were observed at low incidences in all groups including control, but the significantly higher rate of incomplete ossification of supraoccipital or hyoid bones and wavy ribs observed within the highest treated group clearly indicates a substance-dependency.
Justification for classification or non-classification
N-vinylpyrrolidone (NVP) should not be classified as a reproductive or developmental hazard under either the EU DSD classification criteria (Directive 67/548/EEC) or the EU CLP classification criteria (Regulation (EC) 1272/2008) on the basis of negative pathological reproductive organ findings observed in key chronic study (BASF, 1992) and a key guideline Developmental/teratogenicity study (BASF, 2001).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.